European Journal of Case Reports in Internal Medicine


The European Journal of Case Reports in Internal Medicine is an official journal of the European Federation of Internal Medicine (EFIM). The journal wants to promote the practice of internal medicine in Europe. Its aim is to provide a forum to internal medicine doctors.
EJCRIM welcomes papers describing unusual or complex cases and case series that an internist may encounter in everyday practice. Case series are also welcomed as long as they demonstrate the appropiateness of a therapeutical approach or unusual manifestation of a disease.
The journal would also consider brief reasoned reports of issues relevant to the practice of Internal Medicine, as well as Abstracts submitted to scientific meetings of European societies of Internal Medicine.

EJCRIM is peer-reviewed with single-blind review and freely accessible to all.

Madalina Maria Gorgan, Ioana Grigorescu, Dan Lucian Dumitrascu
Youssef Mahmoud, Tamer Shalaby, Nazia Rashid
Chrysostomos S Katsenos, Markos Moukas, Vasiliki Baka, Eleni Kafkoula, Despoina Androulaki, Kostas E Mandragos
Simon Bac, Eric Frans van Bommel
Luis Corral-Gudino, Alicia Rivas-Lazamares, Ana Gonzalez-Fernandez, Juan Carlos Hernando-Garcia
Filipa Silva, Mariana Brandão, Afonso Esteves
Claudia Burkhardt, Eric Eeckhout, Salah Dine Qanadli, John-David Aubert, Jean-Marc Meier
Sara Lopes Guerreiro, Carolina Gouveia, Rita Mora de Féria, Ana Lourenço, Fátima Grenho

Toxic Epidermal Necrolysis and Sepsis

Diana Dias Alves, Nulita Lourenço, Daniela Franco, Eufémio Calmeiro, Rosa Silva
Published: 21/09/2016


A 63-year-old male patient suffered from myalgia, arthralgia cough and erythematous macules, with confluence to the thorax, limbs, thighs and the scrotum. The erythematous macules evolved to blisters with a positive Nikolsky’s sign. A cutaneous biopsy revealed satellite cell necrosis. Administration of immunoglobulins resulted in a favourable evolution of the cutaneous lesions. Toxic epidermal necrolysis (TEN) is a rare and potentially fatal mucocutaneous disease. Early recognition, diagnosis and therapy are of the utmost importance.