Acute severe ulcerative colitis flare complicated by myopericarditis and infliximab-induced hepatitis
  • Magdalini Manti
    Department of Gastroenterology, St Mark’s Hospital, London, UK
  • Nikolaos Kamperidis
    Department of Gastroenterology, St Mark’s Hospital, London, UK
  • Alexandros Toskas
    Department of Gastroenterology, St Mark’s Hospital, London, UK
  • Harry Martin
    Department of Gastroenterology, St Mark’s Hospital, London, UK
  • Ravi Misra
    Department of Gastroenterology, St Mark’s Hospital, London, UK

Keywords

IBD, myopericarditis, CMV, infliximab, transaminitis

Abstract

Ulcerative colitis (UC) is an autoimmune disease associated with both intestinal and extraintestinal manifestations. The latter may include heart complications, such as myopericarditis leading to life-threatening arrythmias. Nowadays, UC is commonly treated with biologic medications and infliximab is the first line therapy in an outpatient setting, while it is also used as rescue therapy in acute severe UC. However, it has been associated with severe immunosuppression, cytomegalovirus (CMV) reactivation and drug-induced hepatitis. We report a case of UC flare in a biologic naïve patient admitted with myopericarditis, which was further complicated by positive CMV biopsies and infliximab-induced transaminitis.

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    Published: 2024-03-01
    Issue: 2024: Vol 11 No 4 (view)

    How to cite:
    1.
    Manti M, Nikolaos Kamperidis, Alexandros Toskas, Harry Martin, Ravi Misra. Acute severe ulcerative colitis flare complicated by myopericarditis and infliximab-induced hepatitis. EJCRIM 2024;11 doi:10.12890/2024_004383.

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