DOI: 10.12890/2025_005393
Baclofen-induced pancreatitis
Authors
elias.fiani@hotmail.com
Keywords
Acute pancreatitis, baclofen, drug-induced pancreatitis, Naranjo scoreAbstract
Acute pancreatitis is an inflammatory condition of the pancreas that can result from various aetiologies, one of them being drug-induced pancreatitis, a relatively rare cause. Drug-induced pancreatitis should be considered in patients presenting with epigastric pain, elevated pancreatic enzymes, and imaging findings consistent with acute pancreatitis, in the absence of any common precipitants such as alcohol, gallstones, trauma. We report a case of acute pancreatitis following the initiation of baclofen therapy, with no other identifiable risk factors. A probable drug adverse reaction was established through the Naranjo Adverse Drug Reaction Probability Scale. This case highlights the need for physicians to consider baclofen as a potential cause of acute pancreatitis.
References
- Bao YK, Ganesan VC, Jiang W, Lin L, Brown NR, Steigerwalt KE, et al. Muscle relaxant induced pancreatitis leading to hyperosmolar hyperglycemic state. Oxf Med Case Reports 2019;2019:omz012.
- de Sousa N, Santos D, Monteiro S, Silva N, Barreiro-Iglesias A, Salgado AJ. Role of Baclofen in Modulating Spasticity and Neuroprotection in Spinal Cord Injury. J Neurotrauma 2022;39:249-258.
- Jones MR, Hall OM, Kaye AM, Kaye AD. Drug-induced acute pancreatitis: a review. Ochsner J 2015;15:45-51.
- Munsell MA, Buscaglia JM. Acute pancreatitis. J Hosp Med 2010;5:241-250.
- Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981;30:239-245.
- Szatmary P, Grammatikopoulos T, Cai W, Huang W, Mukherjee R, Halloran C, et al. Acute Pancreatitis: Diagnosis and Treatment. Drugs 2022;82:1251-1276.
- Trivedi CD, Pitchumoni CS. Drug-induced pancreatitis: an update. J Clin Gastroenterol 2005;39:709-716.
- Warren RL, Davis SM. The Role of Baclofen in the Treatment of Gastroesophageal Reflux Disease. J Pharm Technol 2015;31:258-261.
- Underwood TW, Frye CB. Drug-induced pancreatitis. Clin Pharm 1993;12:440-448.
