DOI: 10.12890/2024_4673

The investigation of B12 deficiency leading to the serendipitous diagnosis of gastric carcinoid tumour

Authors

  • Karam Karam Department of Gastroenterology, Faculty of Medicine, University of Balamand, Beirut, Lebanon
  • Sarah Saleh Faculty of Medicine, University of Balamand, Beirut, Lebanon
  • Houssein Chebbo Faculty of Medicine, University of Balamand, Beirut, Lebanon
  • Sarah Jalloul Department of Gastroenterology, Faculty of Medicine, University of Balamand, Beirut, Lebanon
  • Elias Fiani Department of Internal Medicine, Saint Georges Hospital UMC, Beirut, Lebanon

elias.fiani@hotmail.com

Keywords

Gastric NET, atrophic gastritis, pernicious anaemia

Abstract

Gastric carcinoid is a rare type of gastric malignancy accounting for around 7% of all gastrointestinal neuroendocrine tumours (NETs). While most gastric NETs (gNETs) are readily visible through direct visualisation by upper endoscopy, around 25% of gastric carcinoids are invisible because they are located in the submucosal gastric regions of the body and fundus. gNETs located in the intra-mucosal areas can be identified by gastric mapping; this can be done by taking random gastric biopsies from the antrum, body and fundus.
We report a case of a well-differentiated gastric NET type 1 with atrophic gastritis diagnosed on upper endoscopy and pathological immunohistochemistry staining.

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References

  1. Abraham SC, Carney JA, Ooi A, Choti MA, Argani P. Achlorhydria, parietal cell hyperplasia, and multiple gastric carcinoids: a new disorder. Am J Surg Pathol 2005;29:969–975.
  2. Barchi LC, Jacob CE, Bresciani CJ, Yagi OK, Mucerino DR, Lopasso FP, et al. Minimally invasive surgery for gastric cancer: time to change the paradigm. Arq Bras Cir Dig 2016;29:117–120.
  3. Borch K, Ahrén B, Ahlman H, Falkmer S, Granérus G, Grimelius L. Gastric carcinoids biologic behavior and prognosis after differentiated treatment in relation to type. Ann Surg. 2005;242:64–73.
  4. Burkitt MD, Pritchard DM. Review article: pathogenesis and management of gastric carcinoid tumours. Aliment Pharmacol Ther 2006;24:1305–1320.
  5. Dhruv S, Anwar S, Polavarapu A, Liliane D. Gastric carcinoid: the invisible tumor! Cureus 2021;13:e13556.
  6. Rindi G, Luinetti O, Cornaggia M, Capella C, Solcia E. Three subtypes of gastric argyrophil carcinoid and the gastric neuroendocrine carcinoma: a clinicopathologic study. Gastroenterology 1993;104:994–1006.
  7. Thomas D, Tsolakis AV, Grozinsky-Glasberg S, Fraenkel M, Alexandraki K, Sougioultzis S, et al. Long-term follow-up of a large series of patients with type 1 gastric carcinoid tumors: data from a multicenter study. Eur J Endocrinol 2013;168:185–193.
  8. Plöckinger U. Diagnosis and treatment of gastric neuroendocrine tumours. Wien Klin Wochenschr 2007;119:570–572.
  9. Ahmed M. Gastrointestinal neuroendocrine tumors in 2020. World J Gastrointest Oncol 2020;12:791–807.
  10. Kema IP, de Vries EG, Schellings AM, Postmus PE, Muskiet FA. Improved diagnosis of carcinoid tumors by measurement of platelet serotonin. Clin Chem 1992;38:534–540.
  11. Koffas A, Giakoustidis A, Papaefthymiou A, Bangeas P, Giakoustidis D, Papadopoulos VN, et al. Diagnostic work-up and advancement in the diagnosis of gastroenteropancreatic neuroendocrine neoplasms. Front Surg 2023;10:1064145.
  12. Wardlaw R, Smith JW. Gastric carcinoid tumors. Ochsner J 2008;8:191–196.
  13. Singh D, Arya A, Agarwal A, Agarwal G, Ravina M, Gambhir S. Role of Ga-68 DOTANOC positron emission tomography/computed tomography scan in clinical management of patients with neuroendocrine tumors and its correlation with conventional imaging-experience in a tertiary care center in India. Indian J Nucl Med 2022;37:29–36.

Published

2024-07-29

Issue

Vol. 11 No. 8 (2024)

Categories

How to Cite

1.
Karam K, Saleh S, Chebbo H, Jalloul S, Fiani E. The investigation of B12 deficiency leading to the serendipitous diagnosis of gastric carcinoid tumour. EJCRIM [Internet]. 2024 Jul. 29 [cited 2026 Nov. 3];11(8). Available from: https://ejcrim.com/index.php/ejcrim/article/view/4673

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