DOI: 10.12890/2024_004773
A rare presentation of a large left atrial myxoma with gastrointestinal symptoms
Authors
Samuel.Kim@ttuhsc.edu
Keywords
Atrial myxoma, Interleukin-6, Gastrointestinal symptoms, Constitutional symptomsAbstract
Atrial myxoma is a rare primary tumour of the heart that typically arises from the left atrium. Patients typically present with obstructive symptoms such as dyspnoea, but constitutional and embolic symptoms can be seen as well. Gastrointestinal symptoms in the absence of embolisation are rarely reported in the literature. Our case presents a 55-year-old female who was found to have a large left atrial myxoma after presenting with gastrointestinal symptoms, which resolved upon resection of the tumour. This case illustrates that atrial myxomas can have an atypical presentation with gastrointestinal symptoms, which could be related to inflammation of gastric mucosa from interleukin-6 produced by the tumour cells. Careful history-taking followed by early detection and prompt treatment is important as atrial myxomas can lead to potentially devastating complications.
References
- Oktaviono YH, Saputra PBT, Arnindita JN, Afgriyuspita LS, Kurniawan RB, Pasahari D, et al. Clinical characteristics and surgical outcomes of cardiac myxoma: a meta-analysis of worldwide experience. Eur J Surg Oncol 2024;50:107940.
- Acebo E, Val-Bernal JF, Gómez-Román JJ, Revuelta JM. Clinicopathologic study and DNA analysis of 37 cardiac myxomas: a 28-year experience. Chest 2003;123:1379–1385.
- Wang Z, Chen S, Zhu M, Zhang W, Zhang H, Li H, et al. Risk prediction for emboli and recurrence of primary cardiac myxomas after resection. J Cardiothorac Surg 2016;11:22.
- Azdaki N, Moezi S, Hosseinzadehmaleki M, Farzad M. Failed primary percutaneous coronary intervention in a middle-aged man without cardiovascular risk factors: left atrium myxoma. Pan Afr Med J 2020;36:6.
- Santos MP, Pereira JN, Delabio RW, Smith MAC, Payão SLM, Carneiro LC, et al. Increased expression of interleukin-6 gene in gastritis and gastric cancer. Braz J Med Biol Res 2021;54:e10687.
- Sun P, Wang Z-B. Familial atrial myxoma. Cardiol Young 2008;18:525–527.
- Kamilaris CDC, Faucz FR, Voutetakis A, Stratakis CA. Carney complex. Exp Clin Endocrinol Diabetes 2019;127:156–164.
- Tiraboschi R, Terzi A, Merlo M, Procopio A. Mixoma dell’atrio sinistro. Aspetti clinici e chirurgici in 26 casi operati [Left atrial myxoma. Clinical and surgical features in 26 surgically treated cases]. Ital Heart J Suppl 2000;1:797–802. I