DOI: 10.12890/2023_004064

Spontaneous intracranial hypotension complicated by a cerebral venous thrombosis following an mRNA COVID-19 vaccination: coincidence vs cause?

Authors

  • Anoop Kumar Pandey Department of Radiology, Medeor Hospital, Dubai, United Arab Emirate
  • Taleb Rooeintan Department of Neurology, Burjeel Speciality Hospital, Sharjah, United Arab Emirates

anu29manu@gmail.com

Keywords

Spontaneous intracranial hypotension, cerebral venous thrombosis, m-RNA COVID-19 vaccine, headache

Abstract

Spontaneous intracranial hypotension (SIH) is a rare cause of persistent headache, particularly among young and middle-aged people. A potentially life-threatening complication of SIH is a cerebral venous thrombosis (CVT). The authors present a case in which a patient presented with SIH complicated by CVT one week after receiving a booster dose of mRNA COVID-19 vaccine. According to our literature review, this is the first such case report.

View the entire article

Downloads

References

  1. Schievink WI. Spontaneous spinal cerebrospinal fluid leaks and intracranial hypotension. JAMA 2006;295:2286–2296.
  2. Schievink WI, Maya MM. Cerebral venous thrombosis in spontaneous intracranial hypotension. Headache 2008;48:1511–1519.
  3. Jaiswal V, Nepal G, Dijamco P, Ishak A, Dagar M, Sarfraz Z, et al. Cerebral venous sinus thrombosis following COVID-19 vaccination: a systematic review. J Prim Care Community Health 2022;13:21501319221074450.
  4. Vishteh AG, Schievink WI, Baskin JJ, Sonntag VK. Cervical bone spur presenting with spontaneous intracranial hypotension: case report. J Neurosurg 1998;89:483–484.
  5. Winter SCA, Maartens NF, Anslow P, Teddy, PJ. Spontaneous intracranial hypotension due to thoracic disc herniation: case report. J Neurosurg 2002;96:343–345.
  6. Kranz PG, Amrhein TJ, Gray L. CSF venous fistulas in spontaneous intracranial hypotension: imaging characteristics on dynamic and CT myelography. AJR Am J Roentgenol 2017;209:1360–1366.
  7. Ku J, Chen C-Y, Ku J, Chang H-K, Wu J-C, Yen Y-S. Iatrogenic cerebrospinal fluid leak after repeated nasal swab tests for COVID-19: illustrative case. J Neurosurg Case Lessons 2021;2:CASE21421.
  8. Sibat HF. Intracranial hypotension after severe COVID 19: case report and literature review. Clin Schizophr Relat Psychoses 2021;15.
  9. Tu T-M, Yi SJ, Koh JS, Saffari SE, Hoe RHM, Chen GJ et al. Incidence of cerebral venous thrombosis following SARS-CoV-2 infection vs mRNA SARS-CoV-2 vaccination in Singapore. JAMA Netw Open 2022;5:e222940.
  10. Muir K-L, Kallam A, Koepsell SA, Gundabolu K. Thrombotic thrombocytopenia after Ad26.COV2.S vaccination. N Engl J Med 2021;384:1964–1965.
  11. Fan BE, Shen JY, Lim XR, Tu TM, Chang CCR, Khin HSW, et al. Cerebral venous thrombosis post BNT162b2 mRNA SARS-CoV-2 vaccination: a black swan event. Am. J. Hematol 2021;96:E357–E361.
  12. Costa P, Del Zotto E, Giossi A, Volonghi I, Poli L, Frigerio M, et al. Headache due to spontaneous intracranial hypotension and subsequent cerebral vein thrombosis. Headache 2012;52:1592–1596.
  13. Mokri B. The Monro-Kellie hypothesis: applications in CSF volume depletion. Neurology 2001;56:1746–1748.
  14. Park JH, Yoon SH. New concept of cerebrospinal fluid dynamics in cerebral venous sinus thrombosis. Med Hypotheses 2008;70:143–147.
  15. Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981;30:239–245.

Published

2023-09-19

Issue

Vol. 10 No. 11 (2023)

Categories

How to Cite

1.
Pandey AK, Rooeintan T. Spontaneous intracranial hypotension complicated by a cerebral venous thrombosis following an mRNA COVID-19 vaccination: coincidence vs cause? EJCRIM [Internet]. 2023 Sep. 19 [cited 2026 Nov. 3];10(11). Available from: https://ejcrim.com/index.php/ejcrim/article/view/4064

Most read articles by the same author(s)