DOI: 10.12890/2019_001171

Cerebral Venous Thrombosis and Acute Pulmonary Embolism following Varicella Infection

Authors

  • Rashid Khan Department of Internal Medicine, Belhoul Speciality Hospital, Dubai, UAE
  • Yasmeen Ajaz Department of Internal Medicine, Belhoul Speciality Hospital, Dubai, UAE
  • Anoop Kumar Pandey Department of Radiology, Belhoul Speciality Hospital, Dubai, UAE
  • Khalid AlSaffar Department of Neurology, Belhoul Speciality Hospital, Dubai, UAE
  • Sunil Roy Thottuvelil Narayanan Department of Cardiology, Belhoul Speciality Hospital, Dubai, UAE

sunilroytn@hotmail.com

Keywords

Venous thrombosis, pulmonary embolism, varicella infection, protein S deficiency, hypercoagulable state

Abstract

Varicella infection is caused by varicella-zoster virus (VZV) and commonly presents as a self-limiting skin manifestation in children. VZV also causes cerebral arterial vasculopathy and antibody-mediated hypercoagulable states leading to thrombotic complications in children, although there are very few such reports in adults. Postulated causal factors include vasculitis, direct endothelial damage, or acquired protein S deficiency secondary to molecular mimicry. These induced autoantibodies to protein S could lead to acquired protein S deficiency and produce a hypercoagulable state causing venous sinus thrombosis. Here we report the case of a 26-year-old man who presented with cortical venous sinus thrombosis and acute pulmonary embolism following varicella infection. Both conditions responded to anticoagulation treatment.

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Published

2019-09-20

Issue

Vol. 6 No. 10 (2019)

How to Cite

1.
Khan R, Ajaz Y, Pandey AK, AlSaffar K, Narayanan SRT. Cerebral Venous Thrombosis and Acute Pulmonary Embolism following Varicella Infection. EJCRIM [Internet]. 2019 Sep. 20 [cited 2026 Nov. 3];6(10). Available from: https://ejcrim.com/index.php/ejcrim/article/view/1171

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