DOI: 10.12890/2023_003712

Malignant Syphilis: A Rare Case of Early Secondary Syphilis in an Immunocompetent Patient

Authors

  • Ramiro Sá Lopes Centro Hospitalar Universitário do Algarve, Faro, Portugal
  • Ana Sara Monteiro Centro Hospitalar Universitário do Algarve, Faro, Portugal
  • Rosário Saez Centro Hospitalar Universitário do Algarve, Faro, Portugal
  • Carlos Candeias Centro Hospitalar Universitário do Algarve, Faro, Portugal
  • Catarina Mendonça Centro Hospitalar Universitário do Algarve, Faro, Portugal

rsalopes1602@gmail.com

Keywords

Early secondary syphilis, skin lesions, immunocompetent

Abstract

Early malignant syphilis is an uncommon form of secondary syphilis and characterized by pleomorphic multiple round-to-oval papules, some with necrosis, and associated with systemic signs and symptoms. Usually seen in immunosuppressed patients, mainly those infected with HIV, it can also be observed in immunocompetent patients.
We report a case in a young healthy woman with the characteristic features of the disease and with favourable skin lesion evolution after appropriate treatment with penicillin.

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References

  1. Corti M, Solari R, De Carolis L, Figueiras O, Vittar N, Maronna E. Sífilis maligna en un paciente con infección por VIH. Presentación de un caso y revisión de la literatura. Rev Chilena Infectol 2012;29:678–681. doi: 10.4067/S0716-10182012000700017
  2. Requena CB, Orasmo CR, Ocanha JP, Barraviera SR, Marques ME, Marques SA. Malignant syphilis in an immunocompetent female patient. An Bras Dermatol 2014 Nov-Dec;89(6):970–972. doi: 10.1590/abd1806-4841.20143155
  3. Djawad K. Malignant syphilis as an initial presentation of HIV infection: a case report. Int J Dermatol Venereol 2021;4(3):192–194. doi: 10.1097/JD9.0000000000000162
  4. Rao AG, Swathi T, Hari S, Kolli A, Reddy UD. Malignant syphilis in an immunocompetent adult male. Indian J Dermatol 2017;62(5):524–527. doi: 10.4103/ijd.IJD_733_16
  5. Janier M, Unemo M, Dupin N, Tiplica G, Potocnik M, Patel R. 2020 European guideline on the management of syphilis. J Eur Acad Dermatol Venereol 2021;35:574–588. doi: 10.1111/jdv.16946
  6. Ortigosa YM, Bendazzoli PS, Barbosa AM, Ortigosa LC. Early malignant syphilis. An Bras Dermatol 2016;91(5 Suppl 1):148–150. doi: 10.1590/abd1806-4841.20164491
  7. Fustà-Novell X, Morgado-Carrasco D, Barreiro-Capurro A, Manzardo C, Alsina-Gibert M, et al. Syphilis maligna: a presentation to bear in mind [in English]. Actas Dermosifiliogr (Engl Ed) 2019;110(3):232–237. doi: 10.1016/j.ad.2018.02.024

Published

2023-02-03

How to Cite

1.
Sá Lopes R, Monteiro AS, Saez R, Candeias C, Mendonça C. Malignant Syphilis: A Rare Case of Early Secondary Syphilis in an Immunocompetent Patient. EJCRIM [Internet]. 2023 Feb. 3 [cited 2026 Nov. 3];10(1). Available from: https://ejcrim.com/index.php/ejcrim/article/view/3712

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