DOI: 10.12890/2021_003025

SARS-CoV-2-related Multisystem Inflammatory Syndrome in Adults

Authors

  • Antonio Martins Infectious Diseases Intensive Care Unit, Infectious Diseases Department, Centro Hospitalar Universitário de São João, Porto, Portugal; Department of Medicine, Faculdade de Medicina da Universidade do Porto, Porto, Portugal
  • Sílvia Policarpo Infectious Diseases Intensive Care Unit, Infectious Diseases Department, Centro Hospitalar Universitário de São João, Porto, Portugal; Department of Medicine, Faculdade de Medicina da Universidade do Porto, Porto, Portugal
  • André Silva Pinto Infectious Diseases Intensive Care Unit, Infectious Diseases Department, Centro Hospitalar Universitário de São João, Porto, Portugal; Department of Medicine, Faculdade de Medicina da Universidade do Porto, Porto, Portugal; Nephrology and Infectious Diseases R&D, i3S – Instituto de Investigação e Inovação em Saúde da Universidade do Porto, Porto, Portugal
  • Ana Sofia Santos Infectious Diseases Intensive Care Unit, Infectious Diseases Department, Centro Hospitalar Universitário de São João, Porto, Portugal; Department of Medicine, Faculdade de Medicina da Universidade do Porto, Porto, Portugal
  • Paulo Figueiredo Infectious Diseases Intensive Care Unit, Infectious Diseases Department, Centro Hospitalar Universitário de São João, Porto, Portugal; Department of Medicine, Faculdade de Medicina da Universidade do Porto, Porto, Portugal
  • António Sarmento Infectious Diseases Intensive Care Unit, Infectious Diseases Department, Centro Hospitalar Universitário de São João, Porto, Portugal; Department of Medicine, Faculdade de Medicina da Universidade do Porto, Porto, Portugal; Nephrology and Infectious Diseases R&D, i3S – Instituto de Investigação e Inovação em Saúde da Universidade do Porto, Porto, Portugal
  • Lurdes Santos Infectious Diseases Intensive Care Unit, Infectious Diseases Department, Centro Hospitalar Universitário de São João, Porto, Portugal; Department of Medicine, Faculdade de Medicina da Universidade do Porto, Porto, Portugal; Nephrology and Infectious Diseases R&D, i3S – Instituto de Investigação e Inovação em Saúde da Universidade do Porto, Porto, Portugal

antonio.rm626@gmail.com

Keywords

SARS-CoV-2, multisystem inflammatory syndrome, adult patients

Abstract

Adults infected with SARS-CoV-2 may develop a multisystem inflammatory syndrome (MIS-A) characterized by elevated inflammatory markers and multisystem organ involvement. We report the case of a patient who presented with fever and vomiting at hospital admission. He tested positive for SARS-CoV-2 infection and blood tests showed elevated inflammatory markers. The patient developed acute cardiac dysfunction and shock in less than 24 hours and the echocardiogram revealed an LVEF of 30%. He was discharged 3 weeks later fully recovered. MIS-A should be considered if a compatible syndrome is observed in patients with evidence of SARS-CoV-2 infection by PCR test or serology.

View the entire article

Downloads

References

  1. Centers for Disease Control and Prevention. Information for healthcare providers about multisystem inflammatory syndrome in children (MIS-C). Available from: https://www.cdc.gov/mis-c/hcp/ (accessed 10 Oct 2021).
  2. Centers for Disease Control and Prevention. Multisystem inflammatory syndrome in adults (MIS-A). Available from: https://www.cdc.gov/mis-c/mis-a.html (accessed 10 Oct 2021).
  3. Morris SB, Schwartz NG, Patel P, Abbo L, Beauchamps L, Balan S, et al. Case series of multisystem inflammatory syndrome in adults associated with SARS-CoV-2 infection - United Kingdom and United States, March-August 2020. MMWR Morb Mortal Wkly Rep 2020;69(40):1450–1456. doi:10.15585/mmwr.mm6940e1.
  4. Bastug A, Aslaner H, Bilir YA, Kemirtlek N, Gursoy FM, Bastug S, et al. Multiple system inflammatory syndrome associated with SARS-CoV-2 infection in an adult and an adolescent. Rheumatol Int 2021;41:993–1008. doi:10.1007/s00296-021-04843-1.
  5. Chau VQ, Giustino G, Mahmood K, Oliveros E, Neibart E, Oloomi M, et al. Cardiogenic shock and hyperinflammatory syndrome in young males with COVID-19.Circ Heart Fail 2020;13(10):e007485. doi:10.1161/CIRCHEARTFAILURE.120.007485.
  6. Hékimian G, Kerneis M, Zeitouni M, Cohen-Aubart F, Chommeloux J, Bréchot N, et al. COVID-19 acute myocarditis and multisystem inflammatory syndrome in adult intensive and cardiac care units. Chest 2020;159(2):657–662. doi:10.1016/j.chest.2020.08.2099.
  7. Henderson LA, Canna SW, Friedman KG, Gorelik M, Lapidus SK, Bassiri H, et al. American College of Rheumatology clinical guidance for multisystem inflammatory syndrome in children associated with SARS-CoV-2 and hyperinflammation in pediatric COVID-19: version 2. Arthritis Rheumatol 2021;73(4):e13–29. doi:10.1002/art.41616.

Published

2021-11-26

Issue

Vol. 8 No. 11 (2021)

Categories

How to Cite

1.
Martins A, Policarpo S, Silva Pinto A, Santos AS, Figueiredo P, Sarmento A, et al. SARS-CoV-2-related Multisystem Inflammatory Syndrome in Adults . EJCRIM [Internet]. 2021 Nov. 26 [cited 2026 Nov. 3];8(11). Available from: https://ejcrim.com/index.php/ejcrim/article/view/3025

Most read articles by the same author(s)