DOI: 10.12890/2021_002673

Reactive Thrombocytosis after Splenectomy in Hereditary Spherocytosis: Case Report and Literature Review

Authors

  • Chidinma Ejikeme Internal Medicine Departent, Rutgers-New Jersey Medical School/ Trinitas Regional Medical Center. Elizabeth, NJ, USA
  • Sherif Elkattawy Internal Medicine Departent, Rutgers-New Jersey Medical School/ Trinitas Regional Medical Center. Elizabeth, NJ, USA
  • Fisayo Kayode-Ajala Internal Medicine Departent, Rutgers-New Jersey Medical School/ Trinitas Regional Medical Center. Elizabeth, NJ, USA
  • Sarah Ayad Internal Medicine Departent, Rutgers-New Jersey Medical School/ Trinitas Regional Medical Center. Elizabeth, NJ, USA
  • Abraheim Al-nasseri St. George’s University, West Indies, Grenada
  • William Kessler Department of Hematology and Oncology, Trinitas Regional Medical Center. Elizabeth, NJ, USA

ayadsarah2012@gmail.com

Keywords

Thrombocytosis, splenomegaly, hereditary spherocytosis, thrombosis, hypercoagulable

Abstract

Reactive thrombocytosis after splenectomy is a feared cause of thrombosis throughout the arterial and venous system. There are many causes of splenomegaly, ranging from cirrhosis to lymphoma to hereditary spherocytosis. In this report, we will discuss a case of reactive thrombocytosis after splenectomy in a patient with hereditary spherocytosis. Splenomegaly is a relatively common finding in HD patients, causing extravascular haemolysis and thus leading to haemolytic anaemia. Splenectomy is usually considered when patients start to manifest severe symptoms such as abdominal pain, jaundice or worsening liver function tests. Our patient was a good surgical candidate and successfully underwent splenectomy but afterwards developed arterial and venous thrombosis due to reactive thrombocytosis. An extensive hypercoagulable work-up was unremarkable. The patient was started on hydroxyurea and anticoagulation with eventual improvement of platelet levels.

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References

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Published

2021-07-06

Issue

Vol. 8 No. 7 (2021)

How to Cite

1.
Ejikeme C, Elkattawy S, Kayode-Ajala F, Ayad S, Al-nasseri A, Kessler W. Reactive Thrombocytosis after Splenectomy in Hereditary Spherocytosis: Case Report and Literature Review. EJCRIM [Internet]. 2021 Jul. 6 [cited 2026 Nov. 3];8(7). Available from: https://ejcrim.com/index.php/ejcrim/article/view/2673

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