DOI: 10.12890/2017_000725

Senile Systemic Amyloidosis: An Underdiagnosed Disease

Authors

  • Marta Catarino Manso Internal Medicine Department, Hospital de Egas Moniz, Lisbon
  • Diogo Paixão Marques Internal Medicine Department, Hospital de Egas Moniz, Lisbon
  • Sara L. Rocha Internal Medicine Department, Hospital de Egas Moniz, Lisbon
  • Simão C. Rodeia Emergency Department, Hospital Prof Doutor Fernando da Fonseca, Amadora
  • Raquel Domingos Internal Medicine Department, Hospital de Egas Moniz, Lisbon

martacatarinomanso@hotmail.com

Keywords

Cardiac amyloidosis, senile systemic amyloidosis, amyloidosis, heart failure with preserved ejection fraction.

Abstract

Senile systemic amyloidosis is caused by a non-mutated form of transthyretin with the heart being the major organ involved. This infiltrative cardiomyopathy usually presents as slowly progressive heart failure.
An 82-year-old female patient was admitted for newly diagnosed heart failure. A year later she presented with decompensated heart failure and syncope. Inpatient work-up showed persistently elevated troponin and N-terminal-pro BNP levels, rapid progression to severe left ventricular concentric hypertrophy, and sinus pauses on the Holter. Cardiac MRI revealed diffuse late gadolinium enhancement in the left ventricle. The demonstration of amyloid protein with the clinical findings and complementary investigations allowed for the diagnosis of senile systemic amyloidosis.

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References

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Published

2017-09-21

Issue

Vol. 4 No. 9 (2017)

How to Cite

1.
Manso MC, Paixão Marques D, Rocha SL, Rodeia SC, Domingos R. Senile Systemic Amyloidosis: An Underdiagnosed Disease. EJCRIM [Internet]. 2017 Sep. 21 [cited 2026 Nov. 3];4(9). Available from: https://ejcrim.com/index.php/ejcrim/article/view/725

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