DOI: 10.12890/2026_006493

Folate deficiency-induced pseudo-thrombotic microangiopathy

Authors

  • Adrien Allemand Service de Réanimation Polyvalente, CH Fleyriat, Bourg-en-Bresse, France
  • Remy Favre Laboratoire de Biologie Médicale, CH Fleyriat, Bourg-en-Bresse, France
  • François Dhelft Service de Réanimation Polyvalente, CH Fleyriat, Bourg-en-Bresse, France
  • Nicholas Sedillot Service de Réanimation Polyvalente, CH Fleyriat, Bourg-en-Bresse, France 0009-0009-3222-8097

nsedillot@ch-bourg01.fr

Keywords

Folate deficiency, pseudo-thrombotic microangiopathy, macrocytic anaemia, thrombopenia, high homocysteine levels

Abstract

Pseudo-thrombotic microangiopathy is commonly linked with cyanocobalamin (vitamin B12) deficiency, but its association with folate deficiency is rare. This report details a case involving a 60-year-old man with a background of chronic alcohol use who presented with pancytopenia and schistocytes on his blood smear. Bone marrow aspiration showed erythroblastic hyperplasia with megaloblastic changes indicative of folate deficiency. Both cyanocobalamin and methylmalonic acid levels were normal, and there was no evidence of thrombotic thrombocytopenic purpura. Notably, the patient’s haemoglobin and platelet counts improved after folate supplementation.

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References

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Published

2026-05-05

Issue

Vol. 13 No. 5 (2026)

Categories

How to Cite

1.
Allemand A, Favre R, Dhelft F, Sedillot N. Folate deficiency-induced pseudo-thrombotic microangiopathy. EJCRIM [Internet]. 2026 May 5 [cited 2026 Nov. 3];13(5). Available from: https://ejcrim.com/index.php/ejcrim/article/view/6493