Isolated pulmonary light chain deposition disease

Authors

• Manogna Pendyala Internal Medicine, St Vincent Medical Center, Toledo, USA 0009-0005-7267-8317
• Pranathi Bandarupalli Internal Medicine, St Vincent Medical Center, Toledo, USA
• Purnoor Kaur Internal Medicine, St Vincent Medical Center, Toledo, USA
• Vinod Khatri Pulmonary and Critical Care Medicine, St. Vincent Medical Center, Toledo, USA
• Krishna Khatri Internal medicine, BJ Medical College, Ahmedabad, India

manognapendyala97@gmail.com

Keywords

Abstract

Background: Pulmonary involvement is a significant aspect of many autoimmune diseases. Different pulmonary manifestations of autoimmune diseases encompass a variety of conditions that impact the lungs, including interstitial lung disease, cystic lung disease, pulmonary hypertension, and pleural involvement. One rare manifestation is light-chain deposition disease. Our case report aims to highlight the condition’s rarity and presentation variability.
Case presentation: A 55-year-old Caucasian female with a history of Sjögren’s syndrome, papillary thyroid carcinoma status post thyroidectomy, and chronic leukopenia underwent a computed tomography (CT) of the chest for routine oncological surveillance. Imaging revealed an 8 mm left upper lobe nodule with bilateral bullous lung changes. A positron emission tomography/CT showed mildly ¹⁸F-fluorodeoxyglucose-avid pulmonary nodules with large pneumatoceles, but no evidence of metastatic disease, which increased in size over the next two years, increasing the concern for progressive lung disease. Subsequently, a lung biopsy revealed monotypic kappa light-chain deposition with plasma cell infiltration, establishing the diagnosis of light-chain deposition disease. Despite the radiographic progression, the patient remained asymptomatic and stable. She was managed conservatively with serial paraproteinemia and image-based monitoring.
Conclusion: Pulmonary light chain deposition disease is an infrequent condition requiring a high index of suspicion for diagnosis. Imaging findings can help identify it, but biopsy remains the definitive diagnostic tool. Due to the lack of established management guidelines, treatment is personalized based on disease extent and organ involvement. Further research is needed to understand better this rare entity’s prognosis and optimal treatment approaches.

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