DOI: 10.12890/2026_006063

Clarifying the diagnosis of Epstein-Barr virus related myositis in a genetically confirmed mitochondrial diabetes patient

Authors

  • Michalis Picolos Alithias Endocrinology Center, Nicosia, Cyprus; European University, Nicosia, Cyprus 0000-0003-3562-8810
  • Anna Kyriakidou Royal Free Foundation Trust, Barnet Hospital, London, United Kingdom 0000-0001-8964-8345
  • Anastasia Papapostolou Alithias Endocrinology Center, Nicosia, Cyprus; European University, Nicosia, Cyprus 0000-0002-6157-2761
  • Georgios S. Papaetis K.M.P THERAPIS Paphos Medical Center, Internal Medicine and Diabetes Clinic, Paphos, Cyprus; CDA College, Paphos, Cyprus 0000-0002-8143-7145

picolos_endocrine@yahoo.com

Keywords

Mitochondrial diabetes, MIDD, Epstein-Barr virus, myositis, statins

Abstract

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References

  1. Finsterer J. Only diagnose EBV-related myositis in a patient with mitochondrial myopathy after detecting the virus in the muscle. Int J Adv Multidiscip Res Stud 2025;5:934–935- doi: 10.62225/2583049X.2025.5.5.5027
  2. Kyriakidou A, Papapostolou A, Picolos MK. Epstein-Barr Virus Induced Myositis in a Patient with Mitochondrial Diabetes. Eur J Case Rep Intern Med 2025;12:005197. doi: 10.12890/2025_005197
  3. Kyriakidou A, Hadjivassiliou M, Papapostolou A, Picolos MK. Maternally Inherited Diabetes and Deafness (MIDD) - Atypical Clinical Diabetes Features Leading to the Diagnosis. JCEM Case Rep 2023;1:luad047. doi: 10.1210/jcemcr/luad047
  4. Finsterer J. Mitochondrial diabetes plus phenotypes due to the m.3243A > G variant require correlation with heteroplasmy rates. Clin Case Rep 2024;12:e8862. doi: 10.1002/ccr3.8862
  5. Yang M, Xu L, Xu C, Cui Y, Jiang S, Dong J, et al. The Mutations and Clinical Variability in Maternally Inherited Diabetes and Deafness: An Analysis of 161 Patients. Front Endocrinol (Lausanne) 2021;12:728043. doi: 10.3389/fendo.2021.728043
  6. Murphy R, Turnbull DM, Walker M, Hattersley AT. Clinical features, diagnosis and management of maternally inherited diabetes and deafness (MIDD) associated with the 3243A>G mitochondrial point mutation. Diabet Med 2008;25:383-399. doi: 10.1111/j.1464-5491.2008.02359.x
  7. Guillausseau PJ, Massin P, Dubois-LaForgue D, Timsit J, Virally M, Gin H, et al. Maternally inherited diabetes and deafness: a multicenter study. Ann Intern Med 2001;134:721-728. doi: 10.7326/0003-4819-134-9_part_1-200105010-00008
  8. Ng N, Sanchez-Lechuga B, McCarrick CJ, Mangan C, Burke M, Ioana JA, et al. Mitochondrial heteroplasmy-phenotype correlation and response to glucose lowering therapy in subjects with m.3243A>G mutations. Diabetes Metab 2025;51:101678. doi: 10.1016/j.diabet.2025.101678
  9. Crum-Cianflone NF. Bacterial, fungal, parasitic, and viral myositis. Clin Microbiol Rev 2008;21:473-494. doi: 10.1128/CMR.00001-08
  10. Soares MN, Eggelbusch M, Naddaf E, Gerrits KHL, van der Schaaf M, van den Borst B, et al. Skeletal muscle alterations in patients with acute Covid-19 and post-acute sequelae of Covid-19. J Cachexia Sarcopenia Muscle 2022;13:11-22. doi: 10.1002/jcsm.12896
  11. Kietaibl AT, Fangmeyer-Binder M, Göndör G, Säemann M, Fasching P. Acute viral myositis: profound rhabdomyolysis without acute kidney injury. Wien Klin Wochenschr 2021;133:847-850. doi: 10.1007/s00508-021-01866-3
  12. Singh AK, Sudhan YG, Ramakrishna R, Durairajan SSK. Viral agents in neuromuscular pathology. Int Rev Neurobiol 2025;180:397-434. doi: 10.1016/bs.irn.2025.04.007
  13. Bhai S, Naddaf E, Dimachkie MM. Overview of viral myositis. UpToDate [Internet]. 2024 Sep 24. https://www.uptodate.com/contents/overview-of-viral-myositis
  14. Tanaka T, Takada T, Takagi D, Takeyama N, Kitazawa Y. Acute renal failure due to rhabdomyolysis associated with echovirus 9 infection: a case report and review of literature. Jpn J Med 1989;28:237-242. doi: 10.2169/internalmedicine1962.28.237
  15. Fodili F, van Bommel EF. Severe rhabdomyolysis and acute renal failure following recent Coxsackie B virus infection. Neth J Med 2003;61:177-179.
  16. McCabe JL, Duckett S, Kaplan P. Epstein-Barr virus infection complicated by acute rhabdomyolysis. Am J Emerg Med 1988;6:453-455. doi: 10.1016/0735-6757(88)90244-6
  17. Weiss LM, Chen YY. EBER in situ hybridization for Epstein-Barr virus. Methods Mol Biol 2013;999:223-30. doi: 10.1007/978-1-62703-357-2_16
  18. Melli G, Chaudhry V, Cornblath DR. Rhabdomyolysis: an evaluation of 475 hospitalized patients. Medicine (Baltimore) 2005;84:377-385. doi: 10.1097/01.md.0000188565.48918.41
  19. Authors/Task Force Members; ESC Committee for Practice Guidelines (CPG); ESC National Cardiac Societies. 2019 ESC/EAS guidelines for the management of dyslipidaemias: Lipid modification to reduce cardiovascular risk. Atherosclerosis 2019;290:140-205. doi: 10.1016/j.atherosclerosis.2019.08.014
  20. Hannah-Shmouni F, Al-Sarraf A, Frohlich J, Mezei MM, Sirrs S, Mattman A. Safety of statin therapy in patients with mitochondrial diseases. J Clin Lipidol 2013;7:182. doi: 10.1016/j.jacl.2012.08.003

Published

2026-01-15

How to Cite

1.
Picolos M, Kyriakidou A, Papapostolou A, Papaetis GS. Clarifying the diagnosis of Epstein-Barr virus related myositis in a genetically confirmed mitochondrial diabetes patient. EJCRIM [Internet]. 2026 Jan. 15 [cited 2026 Nov. 3];13(2). Available from: https://ejcrim.com/index.php/ejcrim/article/view/6063

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