DOI: 10.12890/2025_005930

Rosai Dorfman disease: a myriad of presentations-multisystem involvement including bone marrow

Authors

  • Divya Joyce Susai Manickam Department of General Medicine, Flinders Medical Centre, Bedford Park, South Australia, Australia 0009-0009-5019-7255
  • Viswanathan Pandurangan Department of General Medicine, Sri Ramachandra Institute of Higher Education and Research, Chennai, India 0000-0002-2721-9657
  • Manisha Arthur Department of General Medicine, Flinders Medical Centre, Bedford Park, South Australia, Australia 0000-0001-9707-1988
  • Devasena Srinivasan Department of General Medicine, Sri Ramachandra Institute of Higher Education and Research, Chennai, India 0000-0002-5193-4079

sdjoyce3@gmail.com

Keywords

Rosai Dorfman disease, cytopenia, histiocytosis

Abstract

Background: Rosai Dorfman disease (RDD) is a type of histiocytosis which characteristically involves lymph nodes, involvement of other organs is often rare. Histopathological analysis is essential for establishing a definitive diagnosis.
Case report: Our patient had involvement of uncommon sites including bone marrow and spleen at an atypical age of 59 years. Also due to absence of the characteristic CD markers of histiocytes in RDD, we faced certain diagnostic challenges. However, the patient was started on steroids and showed a rapid response. We were able to follow up the patient for nearly a year and have seen improvement in clinical and haematological parameters.
Conclusion: Bone marrow infiltration in RDD is a rare presentation. Improving clinician awareness will lead to earlier detection. Following the guidelines, bone marrow aspiration and biopsy should be done promptly in all patients with cytopenia and will help in early identification of RDD.

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References

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Published

2025-12-03

Issue

Vol. 12 No. 12 (2025)

Categories

How to Cite

1.
Susai Manickam DJ, Pandurangan V, Arthur M, Srinivasan D. Rosai Dorfman disease: a myriad of presentations-multisystem involvement including bone marrow. EJCRIM [Internet]. 2025 Dec. 3 [cited 2026 Nov. 3];12(12). Available from: https://ejcrim.com/index.php/ejcrim/article/view/5930