DOI: 10.12890/2017_000545

Light-Chain Deposition Disease with Prominent Hepatic Involvement

Authors

  • Ana Vaz Cristino Serviço de Medicina Interna, Centro Hospitalar de Trás-os-Montes e Alto Douro, Vila Real
  • Carmen Tavares Pais Serviço de Medicina Interna, Centro Hospitalar de Trás-os-Montes e Alto Douro, Vila Real
  • Renata Violante Silva Serviço de Medicina Interna, Centro Hospitalar de Trás-os-Montes e Alto Douro, Vila Real
  • Paulo Carrola Serviço de Medicina Interna, Centro Hospitalar de Trás-os-Montes e Alto Douro, Vila Real

anavazcristino@gmail.com

Keywords

Light-chain deposition, monoclonal, plasma cell

Abstract

Light-chain deposition disease (LCDD) is a rare monoclonal gammopathy that involves the deposition of light chains (LC) in multiple organs, leading to progressive dysfunction. The kidney is usually the most affected organ and responsible for the initial clinical manifestations. We present the case of a patient with LCDD with prominent liver involvement (marked cholestasis, hepatomegaly and portal hypertension) but with no evidence of coexisting lymphoproliferative disorder.

View the entire article

Downloads

Additional Files

References

  1. Merlini G, Palladini G. Enlightening light chain deposition disease. Blood 2015;126:2770–2771.
  2. Costa S, Dias P, Gaspar E, Cipriano M, Parente F, Lourenço A, et al. Doença de deposição de cadeias leves com atingimento hepático predominante: a propósito de um caso clínico. Rev Port Med Int 2006;13:172–178.
  3. Kumar P, Sandhya V, Venkatakrishnan L, Krishnaveni J, Mohanakrishnan A, Nirmala V. Light chain deposition disease presenting as cholestatic jaundice: a case report. Oman Med J 2012;27:56–59.
  4. Hall C, Peat D. Light chain deposit disease: a frequent cause of diagnostic difficulty. Nephrol Dial Transplant 2001;16:1939–1941.

Published

2017-04-27

Issue

Vol. 4 No. 3 (2017)

How to Cite

1.
Cristino AV, Pais CT, Silva RV, Carrola P. Light-Chain Deposition Disease with Prominent Hepatic Involvement. EJCRIM [Internet]. 2017 Apr. 27 [cited 2026 Nov. 3];4(3). Available from: https://ejcrim.com/index.php/ejcrim/article/view/545

Most read articles by the same author(s)