DOI: 10.12890/2025_005406

A case of intravascular large B-cell lymphoma complicated by hypercalcaemia

Authors

  • Masahiro Yabe Department of General Internal Medicine, Niigata City General Hospital, Niigata, Japan
  • Takashi Abe Department of Hematology, Niigata City General Hospital, Niigata, Japan
  • Saori Yamaga Department of General Internal Medicine, Niigata City General Hospital, Niigata, Japan
  • Seiga Ozaki Department of General Internal Medicine, Niigata City General Hospital, Niigata, Japan
  • Katsuhiro Tomiyama Department of Dermatology, Niigata City General Hospital, Niigata, Japan
  • Hideki Hashidate Department of Pathology, Niigata City General Hospital, Niigata, Japan

yabe0724@jeans.ocn.ne.jp

Keywords

Intravascular large B-cell lymphoma, hypercalcaemia, parathyroid hormone-related protein, humoral hypercalcaemia of malignancy

Abstract

Introduction: Hypercalcaemia in intravascular large B-cell lymphoma (IVLBCL) is extremely rare, occurring more often in other non-Hodgkin’s lymphomas (NHL).
Case description: A 68-year-old man was admitted with a fever of unknown origin, mild disturbance of consciousness and respiratory failure. Laboratory findings showed hypercalcaemia with elevated parathyroid hormone-related protein (PTHrP) and decreased intact parathyroid hormone and 1,25-dihydroxyvitamin D. The patient was diagnosed with IVLBCL via random skin biopsy. Chemotherapy resulted in complete remission and normalised PTHrP levels.
Conclusion: More than half of all cases of hypercalcaemia in NHL are not associated with PTHrP or 1,25-dihydroxyvitamin D, and the cause of the hypercalcaemia is unknown. However, PTHrP levels are elevated in most cases of IVLBCL with hypercalcaemia, which may present as humoral hypercalcaemia of malignancy.

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References

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Histopathological examination of random skin biopsy. Medium-to-large, atypical lymphocytes infiltrated the blood vessels of the specimens

Published

2025-04-23

Issue

Vol. 12 No. 5 (2025)

Categories

How to Cite

1.
Yabe M, Abe T, Yamaga S, Ozaki S, Tomiyama K, Hashidate H. A case of intravascular large B-cell lymphoma complicated by hypercalcaemia. EJCRIM [Internet]. 2025 Apr. 23 [cited 2026 Nov. 4];12(5). Available from: https://ejcrim.com/index.php/ejcrim/article/view/5406

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