DOI: 10.12890/2025_005296
Aspergillus suppurative thyroiditis in the setting of hypogammaglobulinaemia
Authors
tnguyen2@hurleymc.com
Keywords
Suppurative thyroiditis, Aspergillus fumigatus infection, hypogammaglobulinaemiaAbstract
Thyroiditis is a condition characterised by the inflammation of the thyroid gland. Most cases of suppurative thyroiditis are caused by aerobic bacteria and present acute onset of symptoms. Hypogammaglobulinaemia associated with suppurative thyroiditis is extremely rare. This case relates to a diagnosis of Aspergillus suppurative thyroiditis in 78-year-old female patient in a setting of hypogammaglobulinaemia. The patient initially presented with dyspnoea following a recent diagnosis of chronic obstructive pulmonary disease. She developed worsening thyroid pain and swelling, and lab results confirmed hyperthyroidism. Imaging revealed a multinodular goitre, and fine-needle aspiration confirmed Aspergillus fumigatus. After discontinuing antibiotics, voriconazole was started. Due to immunologic workup showing low IgG, intravenous immunoglobulin was administered. Symptoms improved after a 12-week course. This case highlights the importance including differential diagnosis of fungal infection in patients present with acute suppurative thyroiditis and significance of conducting a comprehensive assessment for underlying immunodeficiency.
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