DOI: 10.12890/2016_000511

Delayed Leukoencephalopathy: Three Case Reports and a Literature Review

Authors

  • Ángel Torralba-Morón Internal Medicine Department, University Hospital 12 de Octubre, Madrid
  • Juan Ortiz-Imedio Internal Medicine Department, University Hospital 12 de Octubre, Madrid
  • Montserrat Morales-Conejo Internal Medicine Department, University Hospital 12 de Octubre, Madrid
  • Juan Ruiz-Morales Neurology Department, University Hospital 12 de Octubre, Madrid
  • Juan-Manuel Guerra-Vales Internal Medicine Department, University Hospital 12 de Octubre, Madrid

angelito_torralba@hotmail.com

Keywords

Delayed Leukoencephalopathy, Pale Globes, Methadone

Abstract

Background: Delayed leukoencephalopathy (DL) is a rare entity associated with cerebral hypoxia and heroin consumption. We describe the clinical course of three cases of DL due to non-heroin drug use.

Material and methods: We describe the cases of three DL patients admitted to our hospital in 2012.

Discussion: These cases contribute to the aetiological spectrum of DL since multifactorial causes could account for the clinical symptoms.

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References

  1. Filley C, Kleinschmidt-DeMasters BK. Toxic leukoencephalopathy. N Engl J Med 2001;345:425-432.
  2. Carroll I, Heritier AC, Dirren E, Burkhard PR, Horvath J. Delayed leukoencephalopathy after alprazolam and methadone overdose: a case report and review of the literature. Clin Neurol Neurosurg 2012;114:816–819.
  3. Shprecher D, Mehta L. The syndrome of delayed post-hypoxic leukoencephalopathy. NeuroRehabilitation 2010;26:65–72.
  4. Cerase A, Leonini S, Bellini M, Chianese G, Venturi C. Methadone-induced toxic leukoencephalopathy: diagnosis and follow-up by magnetic resonance imaging including diffusion-weighted imaging and apparent diffusion coefficient maps. J Neuroimaging 2011;21:283–286.
  5. Wolters EC, van Wijngaarden GK, Stam FC, Rengelink H, Lousberg RJ, Schipper ME et al. Leucoencephalopathy after inhaling heroin pyrolysate. Lancet 1982;2:1233–1237.

Published

2017-03-27

Issue

Vol. 4 No. 2 (2017)

How to Cite

1.
Torralba-Morón Á, Ortiz-Imedio J, Morales-Conejo M, Ruiz-Morales J, Guerra-Vales J-M. Delayed Leukoencephalopathy: Three Case Reports and a Literature Review. EJCRIM [Internet]. 2017 Mar. 27 [cited 2026 Nov. 3];4(2). Available from: https://ejcrim.com/index.php/ejcrim/article/view/511