DOI: 10.12890/2024_005032

A posterior cranial fossa lesion mimicking myasthenia gravis

Authors

  • Syed Wajihullah Shah Khyber Medical College, Peshawar, Pakistan
  • Maryam Khalil Department of Neurology, Pakistan Institute of Medical Sciences, Islamabad, Pakistan
  • Mansoor Iqbal Department of Neurology, Pakistan Institute of Medical Sciences, Islamabad, Pakistan
  • Arham Arif Kundi Khyber Medical College, Peshawar, Pakistan
  • Muhammad Hassaan Khyber Medical College, Peshawar, Pakistan

wajih2947@gmail.com

Keywords

Myasthenia gravis, posterior cranial fossa, ptosis, meningioma, neuromuscular junction

Abstract

A 41-year-old male with prior diagnosis of seronegative myasthenia gravis presented with complaints of bilateral ptosis, dysphagia, nasal voice and nasal regurgitation. Despite treatment with pyridostigmine, there was lack of significant improvement in the symptoms. Further investigations, including antibody assays and nerve conduction studies did not support the diagnosis. Magnetic resonance imaging revealed a lesion in the posterior cranial fossa, consistent with meningioma, which was compressing surrounding structures. This case highlights the importance of imaging techniques and considering alternative diagnosis in patients with unusual presentations to ensure appropriate management.

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References

  1. Dresser L, Wlodarski R, Rezania K, Soliven B. Myasthenia Gravis: Epidemiology, Pathophysiology and Clinical Manifestations. J Clin Med 2021;10:2235.
  2. Pasnoor M, Dimachkie MM, Farmakidis C, Barohn RJ. Diagnosis of Myasthenia Gravis. Neurol Clin 2018;36:261-274.
  3. Vinciguerra C, Bevilacqua L, Lupica A, Ginanneschi F, Piscosquito G, Rini N, et al. Diagnosis and Management of Seronegative Myasthenia Gravis: Lights and Shadows. Brain Sci 2023;13:1286.
  4. Frisby J, Wills A, Jaspan T. Brain stem compression by a giant vertebrobasilar aneurysm mimicking seronegative myasthenia. J Neurol Neurosurg Psychiatry 2001;71:125-126.
  5. Shams PN, Waldman A, Plant GT. B Cell lymphoma of the brain stem masquerading as myasthenia. J Neurol Neurosurg Psychiatry 2002;72:271-273.
  6. Kumar S, Shukla R. Midbrain tuberculoma presenting as partial ptosis. BMJ Case Rep 2014;2014: 10.1136/bcr-2014-207686.
  7. Sarkar S, Patra C, Dasgupta MK. Bilateral ptosis without upward gaze palsy: Unusual presentation of midbrain tuberculoma. J Neurosci Rural Pract 2017;8:129-132.

Published

2024-11-25

How to Cite

1.
Shah SW, Khalil M, Iqbal M, Kundi AA, Hassaan M. A posterior cranial fossa lesion mimicking myasthenia gravis. EJCRIM [Internet]. 2024 Nov. 25 [cited 2026 Nov. 4];11(12). Available from: https://ejcrim.com/index.php/ejcrim/article/view/5032