DOI: 10.12890/2025_004963

Would you rather treat? A rare case of Mycobacterium scrofulaceum

Authors

  • Junaid Zafar Sheikh Respiratory Medicine, University Hospital Limerick, Limerick, Ireland
  • Nonhlanhla Lunjani Respiratory Medicine, University Hospital Limerick, Limerick, Ireland; APC Microbiome Ireland, University College Cork, Cork, Ireland; Division of Dermatology, University of Cape Town, Cape Town, South Africa
  • Hira Gul Respiratory Medicine, University Hospital Limerick, Limerick, Ireland
  • Louay Kila Respiratory Medicine, University Hospital Limerick, Limerick, Ireland
  • Brian Casserly Respiratory Medicine, University Hospital Limerick, Limerick, Ireland

junaid.zafar238@hotmail.com

Keywords

Non-tuberculous Mycobacterium, pulmonary Mycobacterium scrofulaceum

Abstract

Mycobacterium scrofulaceum is a rare cause of non-tuberculous mycobacterial infection in adults, primarily affecting the immunocompromised. Pulmonary involvement has been seen in individuals with pre-existing lung pathology. We report a case of a 63-year-old female who presented with abdominal pain, cough and sputum samples yielding M. scrofulaceum, with a normal clinical examination. Initial investigations were unremarkable, prompting abdomen and pelvis computed tomography (CT), revealing minimal pericardial and ascitic fluid. Thoracic CT exhibited calcified tree-in-bud nodules and a trivial left pleural effusion. Given subdued symptoms and limited disease, discerning colonisation versus clinically relevant infection was uncertain. Due to lack of empirical data for guidance, treatment approaches at this juncture remain unclear. The patient was monitored closely for a period of one year with a plan to treat should there be evidence of active disease.

View the entire article

Downloads

References

  1. Pedro B, Alves L, Magano R, Nunes T, Marques N. Scrofula caused by multidrug-resistant tuberculosis. Eur J Case Rep Intern Med 2020;7:001390.
  2. Johnson MM, Odell JA. Nontuberculous mycobacterial pulmonary infections. J Thorac Dis 2014;6:210–220.
  3. Lindeboom JA, Kuijper EJ, Bruijnesteijn van Coppenraet ES, Lindeboom R, Prins JM. Surgical excision versus antibiotic treatment for nontuberculous mycobacterial cervicofacial lymphadenitis in children: a multicenter, randomized, controlled trial. Clin Infect Dis 2007;44:1057–1064.
  4. Wilson JW, Jagtiani AC, Wengenack NL. Mycobacterium scrofulaceum disease: experience from a tertiary medical centre and review of the literature. Infect Dis (Lond) 2019;51:602–609.
  5. Falkinham JO 3rd. Environmental sources of nontuberculous mycobacteria. Clin Chest Med 2015;36:35–41.
  6. Glassroth J: Pulmonary disease due to nontuberculous mycobacteria. Chest 2008;133:243–251. Erratum in: Chest 2008;133:1291.
  7. Suzuki S, Morino E, Ishii M, Namkoong H, Yagi K, Asakura T, et al. Clinical characteristics of pulmonary Mycobacterium scrofulaceum disease in 2001–2011: a case series and literature review. J Infect Chemother 2016:22:611–616.
  8. Griffith DE, Aksamit T, Brown-Elliott BA, Catanzaro A, Daley C, Gordin F, et al. ATS Mycobacterial Diseases Subcommittee; American Thoracic Society; Infectious Disease Society of America. An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases. Am J Respir Crit Care Med 2007;175:367–416.
  9. Stoichitoiu LE, Ionescu GD, Neatu I, Baicus C. Causes of polyserositis: a systematic review. J Pers Med 2023;13:834.
  10. Zimmermann P, Tebruegge M, Curtis N, Ritz N. The management of non-tuberculous cervicofacial lymphadenitis in children: a systematic review and meta-analysis. J Infect 2015;71:9–18.

Published

2025-01-07

How to Cite

1.
Sheikh JZ, Lunjani N, Gul H, Kila L, Casserly B. Would you rather treat? A rare case of Mycobacterium scrofulaceum. EJCRIM [Internet]. 2025 Jan. 7 [cited 2026 Nov. 3];12(2). Available from: https://ejcrim.com/index.php/ejcrim/article/view/4963

Most read articles by the same author(s)