DOI: 10.12890/2024_004818

Malignant peripheral nerve sheath tumor presenting as sciatica in a patient with neurofibromatosis type 1: is magnetic resonance imaging an effective screening tool?

Authors

  • Adisalem M. Teferi Division of Internal Medicine, Department of Medicine, St. Barnabas Hospital, New York, USA
  • Sangam Sangam Division of Internal Medicine, Department of Medicine, St. Barnabas Hospital, New York, USA
  • Azana Newman Division of Internal Medicine, Department of Medicine, St. Barnabas Hospital, New York, USA
  • Osman Alvarado Division of Internal Medicine, Department of Medicine, St. Barnabas Hospital, New York, USA
  • Irvianny Madera Division of Internal Medicine, Department of Medicine, St. Barnabas Hospital, New York, USA
  • Julian Paniagua Division of Internal Medicine, Department of Medicine, St. Barnabas Hospital, New York, USA

space.sangam1@gmail.com

Keywords

Malignant peripheral nerve sheath tumor, MPNST, NF-1, magnetic resonance imaging, sciatica, neurofibromatosis type I

Abstract

Peripheral malignant nerve sheath tumours (MPNST) are rare and aggressive soft tissue sarcomas often associated with neurofibromatosis type I (NF-1). We describe a case of a 26-year-old female with NF-1, initially misdiagnosed as sciatica, who was later found to have a malignant spindle cell peripheral nerve sheath tumour of the right sciatic nerve. Magnetic resonance imaging (MRI) proved to be a valuable tool for diagnosis. This case illustrates the importance of considering the transformation of neurofibromas into MPNST as a potential cause of worsening neuropathic pain in patients with NF-1. Given the overlap in clinical presentation with benign conditions, we analyse the utility of MRI for early screening for. Early detection is crucial to improve the chances of cure and prolonged disease-free survival.

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References

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Published

2024-10-24

Issue

Vol. 11 No. 11 (2024)

Categories

How to Cite

1.
Teferi AM, Sangam S, Newman A, Alvarado O, Madera I, Paniagua J. Malignant peripheral nerve sheath tumor presenting as sciatica in a patient with neurofibromatosis type 1: is magnetic resonance imaging an effective screening tool? EJCRIM [Internet]. 2024 Oct. 24 [cited 2026 Nov. 4];11(11). Available from: https://ejcrim.com/index.php/ejcrim/article/view/4818

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