DOI: 10.12890/2024_004679
Elevated procalcitonin levels can occur in bacterial infections and also in medullary thyroid carcinoma
Authors
tareqalsafadi00@yahoo.com
Keywords
Procalcitonin, calcitonin, medullary thyroid carcinoma, sigmoid colon tumour, carcinoembryonic antigen (CEA)Abstract
Medullary thyroid carcinoma (MTC) is a rare and challenging type of thyroid cancer originating from parafollicular cells (C cells) that produce calcitonin. Diagnosing and monitoring this carcinoma can be complex due to its unique biomarkers. Procalcitonin (PCT), a precursor of calcitonin, and carcinoembryonic antigen (CEA) are important markers for MTC. Elevated PCT levels, particularly when they remain high post-infection treatment, and elevated CEA levels are significant indicators for suspecting MTC. This report emphasises the diagnostic and prognostic importance of these biomarkers in MTC, highlighting their roles in detecting and monitoring disease progression. Integrating PCT and CEA measurements into routine clinical practice can enhance detection, provide understanding of therapeutic responses and aid in the effective management of MTC.
References
- Kim M, Kim BH. Current guidelines for management of medullary thyroid carcinoma. Endocrinol Metab (Seoul) 2021;36:514–524.
- Kankanala VL, Mukkamalla SKR. Carcinoembryonic antigen. 2023 Jan 23. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2024 Jan-. PMID: 35201700
- Velissaris D, Zareifopoulos N, Lagadinou M, Platanaki C, Tsiotsios K, Stavridis EL, et al. Procalcitonin and sepsis in the emergency department: an update. Eur Rev Med Pharmacol Sci 2021;25:466–479.
- Becker KL, Nylén ES, White JC, Müller B, Snider RH Jr. Clinical review 167: procalcitonin and the calcitonin gene family of peptides in inflammation, infection, and sepsis: a journey from calcitonin back to its precursors. J Clin Endocrinol Metab 2004;89:1512–1525.
- Jiun-Lih Jerry Lin A, Vail, KA. Procalcitonin (PCT). Medscape 2021. Available at: https://emedicine.medscape.com/article/2096589-overview
- Trimboli P, Giovanella L. Procalcitonin as marker of recurrent medullary thyroid carcinoma: a systematic review and meta-analysis. Endocrinol Metab (Seoul) 2018;33:204–210.
- Fakih MG, Padmanabhan A. CEA monitoring in colorectal cancer. What you should know. Oncology (Williston Park) 2006;20:579–587
- Lakemeyer L, Sander S, Wittau M, Henne-Bruns D, Kornmann M, Lemke J. Diagnostic and prognostic value of CEA and CA19-9 in colorectal cancer. Diseases 2021;9:21.
- Turkdogan S, Forest VI, Hier MP, Tamilia M, Florea A, Payne RJ. Carcinoembryonic antigen levels correlated with advanced disease in medullary thyroid cancer. J Otolaryngol Head Neck Surg 2018;47:55.
