DOI: 10.12890/2024_004621

Refractory depressive disorder as the first manifestation of adolescent Sjögren’s syndrome, successfully treated with rituximab

Authors

  • Amal El-Ouakhoumi Department of Internal Medicine, University Hospital Center Mohammed VI, Marrakech, Morocco
  • Hajar Joulal Department of Internal Medicine, University Hospital Center Mohammed VI, Marrakech, Morocco
  • Jaouad Yousfi Department of Internal Medicine, University Hospital Center Mohammed VI, Marrakech, Morocco
  • Laila Benjilali Department of Internal Medicine, University Hospital Center Mohammed VI, Marrakech, Morocco
  • Mouna Zahlane Department of Internal Medicine, University Hospital Center Mohammed VI, Marrakech, Morocco
  • Lamiaa Essaadouni Department of Internal Medicine, University Hospital Center Mohammed VI, Marrakech, Morocco

amal.elouakhoumi@gmail.com

Keywords

Primary Sjögren’s syndrome, depression, rituximab

Abstract

Background: The psychiatric manifestations of Sjögren’s syndrome are often overlooked despite their prevalence. They can be revelatory of the disease and include anxiety, depression, dementia and, rarely, psychosis.
Case description: We report a case of 18-year-old female in whom a major depressive syndrome revealed primary Sjögren’s disease, with a favourable outcome after treatment with rituximab.
Conclusion: The diagnostic of Sjögren’s syndrome should be considered in patients who present with unexplained and refractory neuropsychiatric symptoms, even in the absence of sicca symptoms.

View the entire article

Downloads

References

  1. li>Wong JKF, Nortley R, Andrews T, D’Cruz D. Psychiatric manifestations of primary Sjögren’s syndrome: a case report and literature review. BMJ Case Rep 2014;2014:bcr2012008038.
  2. Morreale M, Marchione P, Giacomini P, Pontecorvo S, Marianetti M, Vento C, et al. Neurological involvement in primary Sjögren syndrome: a focus on central nervous system. PloS One 2014;9:e84605.
  3. Low S, Gruber A, Weinberg J, Roesch-Ely D, Bendszus M, Wolf RC. Psychiatrische Manifestationen eines primären Sjögren-Syndroms [Psychiatric manifestations of primary Sjögren’s syndrome]. Nervenarzt 2015;86:884–886.
  4. Rosello R, Girela-Serrano B, Gómez S, Baig B, Lim M, Taylor S. Characterizing the features and course of psychiatric symptoms in children and adolescents with autoimmune encephalitis. Eur Arch Psychiatry Clin Neurosci 2022;272:477–482.
  5. Cui Y, Li L, Yin R, Zhao Q, Chen S, Zhang Q, et al. Depression in primary Sjögren’s syndrome: a systematic review and meta-analysis. Psychol Health Med 2018;23:198–209.
  6. Lee YT, Wu CY, Chou IJ, Liu CH. Sjogren’s syndrome related autoimmune encephalopathy presenting as depression and involuntary agitation in a 15-year-old girl: a case report. Front Immunol 2023;14:1145948.
  7. Hammett EK, Fernandez-Carbonell C, Crayne C, Boneparth A, Cron RQ, Radhakrishna SM. Adolescent Sjogren’s syndrome presenting as psychosis: a case series. Pediatr Rheumatol Online J 2020;18:15.
  8. Appenzeller S, Andrade SO, Bombini MF, Sepresse SR, Reis F, França MC Jr. Neuropsychiatric manifestations in primary Sjogren syndrome. Expert Rev Clin Immunol 2022;18:1071–1081.

Published

2024-06-11

Issue

Vol. 11 No. 7 (2024)

Categories

How to Cite

1.
El-Ouakhoumi A, Joulal H, Yousfi J, Benjilali L, Zahlane M, Essaadouni L. Refractory depressive disorder as the first manifestation of adolescent Sjögren’s syndrome, successfully treated with rituximab. EJCRIM [Internet]. 2024 Jun. 11 [cited 2026 Nov. 4];11(7). Available from: https://ejcrim.com/index.php/ejcrim/article/view/4621

Most read articles by the same author(s)