DOI: 10.12890/2016_000446

Prasugrel and Acquired Thrombotic Thrombocytopenic Purpura Associated with ADAMTS13 Activity Deficiency

Authors

  • Yanet Parodis Lopez Dr Negrin General University Hospital, Las Palmas de Gran Canaria, Las Palmas,
  • Nery Sablon Gonzalez Dr Negrin General University Hospital, Las Palmas de Gran Canaria, Las Palmas,
  • Noel Lorenzo Villalba Dr Negrin General University Hospital, Las Palmas de Gran Canaria, Las Palmas,
  • Rafael Camacho Galvan Dr Negrin General University Hospital, Las Palmas de Gran Canaria, Las Palmas,
  • Jose Carlos Rodriguez Perez Dr Negrin General University Hospital, Las Palmas de Gran Canaria, Las Palmas,

noellorenzo@gmail.com

Keywords

Thrombotic microangiopathy, thrombotic thrombocytopenic purpura, prasugrel

Abstract

We report a case of a 64-year-old male who, 44 days after starting treatment with prasugrel, presented with severe thrombocytopenia, anemia, renal failure, and severe ADAMTS13 activity deficiency, along with a high titer of autoantibodies to this protease.

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References

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  4. Jacob S, Dunn BL, Qureshi ZP, et al. Ticlopidine, Clopidogrel and Prasugrel-Associated Thrombotic Thrombocytopenic Purpura: A 20-Year Review from the Southern Network on Adverse Reactions (SONAR). Semin Thromb Hemost 2012;38:845-853.
  5. Zakarija A, Kwaan HC, Moake JL. Ticlopidine and clopidogrel-associated thrombotic thrombocytopenic purpura (TTP): Review of clinical, laboratory, epidemiological and pharmaco vigilance findings (1989–2008). Kidney Int 2009;75:S20-S24.

Published

2016-07-27

Issue

Vol. 3 No. 5 (2016)

How to Cite

1.
Lopez YP, Gonzalez NS, Villalba NL, Galvan RC, Perez JCR. Prasugrel and Acquired Thrombotic Thrombocytopenic Purpura Associated with ADAMTS13 Activity Deficiency. EJCRIM [Internet]. 2016 Jul. 27 [cited 2026 Nov. 4];3(5). Available from: https://ejcrim.com/index.php/ejcrim/article/view/446

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