DOI: 10.12890/2024_004390

Severe gastrointestinal cytomegalovirus infection in a patient diagnosed with late onset combined immunodeficiency

Authors

  • Georgina Sauqué Pintos Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona, Spain
  • Arnau Antolí Gil Department of Internal Medicine, Bellvitge University Hospital
  • Gemma Rocamora Blanch Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona, Spain; Adult Primary Immunodeficiency Unit, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona, Spain
  • Renzo Avila Espinoza Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona, Spain; Adult Primary Immunodeficiency Unit, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona, Spain
  • Rosario Taco Sánchez Department of Anatomical Pathology, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona, Spain
  • Núria Sabé Fernández Adult Primary Immunodeficiency Unit, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona, Spain; Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, Barcelona, Spain
  • Xavier Solanich Moreno Department of Internal Medicine, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona, Spain; Adult Primary Immunodeficiency Unit, Bellvitge University Hospital, L’Hospitalet de Llobregat, Barcelona, Spain

aantolig@bellvitgehospital.cat

Keywords

Primary Immunodeficiency, late onset combined immunodeficiency, opportunistic infection, cytomegalovirus

Abstract

Late onset combined immunodeficiency (LOCID) is a rare variant of common variable immunodeficiency (CVID), typically affecting adult patients who present with opportunistic infections (OI) and/or low CD4+ T lymphocytes. Diagnostic delay is common due to the rareness of this entity, increasing morbidity and mortality. We report on a 66-year-old male who developed a severe gastrointestinal cytomegalovirus (CMV) infection, refractory to antiviral treatment and anti-cytomegalovirus specific human immunoglobulin administration, with a fatal outcome due to an undiagnosed LOCID.

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Published

2024-05-13

Issue

Vol. 11 No. 6 (2024)

Categories

How to Cite

1.
Sauqué Pintos G, Antolí Gil A, Rocamora Blanch G, Avila Espinoza R, Taco Sánchez R, Sabé Fernández N, et al. Severe gastrointestinal cytomegalovirus infection in a patient diagnosed with late onset combined immunodeficiency. EJCRIM [Internet]. 2024 May 13 [cited 2026 Nov. 4];11(6). Available from: https://ejcrim.com/index.php/ejcrim/article/view/4390