DOI: 10.12890/2016_000439

Ventricular Fibrillation in Patient with Multi-vessel Coronary Spasm Four Days after the Initiation of Oral Beta-blocker

Authors

  • Manabu Kurabayashi Division of Cardiology, Yokohama City Minato Red Cross Hospital, Yokohama City
  • Hidetoshi Suzuki Division of Cardiology, Yokohama City Minato Red Cross Hospital, Yokohama City
  • Tsukasa Shimura Division of Cardiology, Yokohama City Minato Red Cross Hospital, Yokohama City
  • Yasuteru Yamauchi Division of Cardiology, Yokohama City Minato Red Cross Hospital, Yokohama City
  • Kaoru Okishige Division of Cardiology, Yokohama City Minato Red Cross Hospital, Yokohama City

kurabayashi.card@yokohama.jrc.or.jp

Keywords

Coronary spasm, ventricular fibrillation, beta-blocker, acetylcholine provocation test.

Abstract

We describe a case of ventricular fibrillation occurring in a patient with multi-vessel coronary spasm after the initiation of an oral beta-blocker. A 56-year-old man began to experience chest discomfort and his computed tomography revealed intermediate coronary stenoses. He was administered medications including an oral beta-blocker but suddenly collapsed while walking 4 days later. An automated external defibrillator detected ventricular fibrillation and delivered successful electrical cardioversion. An acetylcholine provocation test after stabilization of the status revealed triple-vessel coronary spasm. Beta-blockers may provoke exacerbation of coronary spasm and result in lethal arrhythmia.

View the entire article

Downloads

Additional Files

References

  1. Robertson RM, Wood AJ, Vaughn WK, Robertson D. Exacerbation of vasotonic angina pectoris by propranolol. Circulation 1982;65:281–285.
  2. Takagi Y, Yasuda S, Tsunoda R, Ogata Y, Seki A, Sumiyoshi T, et al. Clinical characteristics and long-term prognosis of vasospastic angina patients who survived out-of-hospital cardiac arrest: multicenter registry study of the Japanese Coronary Spasm Association. Circ Arrhythm Electrophysiol 2011;4:295–302.
  3. Kaplan NM. Kaplan’s Clinical Hypertension. 8th ed. Philadelphia: Lippincott Williams & Wilkins, 2002:261–267.
  4. Myerburg RJ, Kessler KM, Mallon SM, Cox MM, deMarchena E, Interian A Jr, et al. Life-threatening ventricular arrhythmias in patients with silent myocardial ischemia due to coronary-artery spasm.N Engl J Med 1992;326:1451–1455.
  5. Krahn AD, Healey JS, Chauhan V, Birnie DH, Simpson CS, Champagne J, et al. Systematic assessment of patients with unexplained cardiac arrest: Cardiac Arrest Survivors with Preserved Ejection Fraction Registry (CASPER). Circulation 2009;120:278–285.

Published

2016-07-27

How to Cite

1.
Kurabayashi M, Suzuki H, Shimura T, Yamauchi Y, Okishige K. Ventricular Fibrillation in Patient with Multi-vessel Coronary Spasm Four Days after the Initiation of Oral Beta-blocker. EJCRIM [Internet]. 2016 Jul. 27 [cited 2026 Nov. 3];3(5). Available from: https://ejcrim.com/index.php/ejcrim/article/view/439