DOI: 10.12890/2014_000042

Can This Be Considered Fondaparinux-induced Thrombocytopenia?

Authors

  • Barbara Mariotti Internal Medicine Department, Azienda Ospedaliero-Universitaria S.Maria della Misericordia, Udine, Italy
  • Paolo Rossi Internal Medicine Department, Azienda Ospedaliero-Universitaria S.Maria della Misericordia, Udine, Italy
  • Enrico Barboni Internal Medicine Department, Azienda Ospedaliero-Universitaria S.Maria della Misericordia, Udine, Italy

barbaramariotti@libero.it

Abstract

We present a case of an old woman with previously documented heparin-induced thrombocytopenia (HIT),treated with fondaparinux, who presented with thrombocytopenia and venous thrombosis after exposure to a preventive dose of fondaparinux duringorthopaedic surgery.
Any accidental exposure to heparin was avoided. Other causes of thrombocytopenia were excluded andantigenic tests combined with clinical probability made a diagnosis of HIT likely.
Can this be considered a possible case of fondaparinux-related HIT, despite the intense and earlydecrease in platelets, as usually happens in rapid-onset HIT, and the fact that previous exposure to fondaparinux had occurred 5 months previously?

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References

  1. Linkins L-A, Dans AL, Moores LK et al. Treatment and prevention of heparin-induced thrombocytopenia: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines, Chest 2012;141:S495–S528.
  2. Warkentin TE. HIT lights: a career perspective on heparin-induced thrombocytopenia, Am J Hematol 2012;87:S92–S99.
  3. Cuker A, Arepally G, Crowther MA et al. The HIT Expert Probability (HEP) Score: a novel pre-test probability model for heparin-induced thrombocytopenia based on broad expert opinion, J Thromb Haemost 2010;8:2642–2650.
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  5. Alsaleh KA, Al-Nasser SM, Bates SM et al. Delayed-onset HIT caused by low-molecular-weight heparin manifesting during fondaparinux propylaxis, Am J Hematol 2008;83(11):876–878.

Published

2014-04-16

Issue

Vol. 1 No. 1 (2014)

How to Cite

1.
Mariotti B, Rossi P, Barboni E. Can This Be Considered Fondaparinux-induced Thrombocytopenia? EJCRIM [Internet]. 2014 Apr. 16 [cited 2026 Nov. 3];1(1). Available from: https://ejcrim.com/index.php/ejcrim/article/view/42