DOI: 10.12890/2023_004041

Linezolid-induced pancreatitis associated with lactic acidosis and relative hypoglycemia: A rare case report

Authors

  • Gi Eun Kim Department of Internal Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar
  • Soubiya Ansari Department of Internal Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar
  • Ateeque Ali Weill Cornell Medicine-Qatar, Doha, Qatar
  • Ehab Adams Department of Internal Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar
  • Mugahid Eltahir Department of Internal Medicine, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar; Department of Medical Intensive Care Unit, Hamad General Hospital, Hamad Medical Corporation, Doha, Qatar

gkim@hamad.qa

Keywords

Drug-induced pancreatitis, acute pancreatitis, linezolid side effect

Abstract

Background: Linezolid is known to cause side effects, including nausea, diarrhea, and headaches of short duration. As extended use of linezolid is becoming more common, additional rare side effects should be considered.
Case Presentation: A 68-year-old man hospitalized for osteomyelitis developed severe abdominal pain and altered mental status following five weeks of linezolid therapy. Laboratory studies showed very high lipase levels, lactic acidosis not responding to resuscitation, and relative hypoglycemia. All common causes of pancreatitis were ruled out, and a trial of linezolid withdrawal was done resulting in drastic improvement in the patient's clinical status.
Conclusions: For patients on extended course of linezolid who develop abdominal pain, drug-induced pancreatitis should be considered as a side effect, and a trial of withdrawal of linezolid should be undertaken.

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References

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Published

2023-08-31

Issue

Vol. 10 No. 10 (2023)

Categories

How to Cite

1.
Kim GE, Ansari S, Ali A, Adams E, Eltahir M. Linezolid-induced pancreatitis associated with lactic acidosis and relative hypoglycemia: A rare case report. EJCRIM [Internet]. 2023 Aug. 31 [cited 2026 Nov. 3];10(10). Available from: https://ejcrim.com/index.php/ejcrim/article/view/4041

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