DOI: 10.12890/2014_000040

Chronic Active Hepatitis B with HBV-Associated Nephropathy: Close Resemblance to Lupus Nephritis

Authors

  • Amitesh Aggarwal Department of Medicine, University College of Medical Sciences, GTB Hospital, Delhi, India
  • Mukul P Agarwal Department of Medicine, University College of Medical Sciences, GTB Hospital, Delhi, India
  • Surendra Rajpal Department of Medicine, University College of Medical Sciences, GTB Hospital, Delhi, India
  • Vineeta V Batra Department of Pathology, Govind Ballabh Pant hospital, New Delhi, India
  • Ankit Kumar Sahu Department of Medicine, University College of Medical Sciences, GTB Hospital, Delhi, India

dramitesh@gmail.com

Abstract

We present a rare case of a 23-year-old male incidentally detected with hepatitis B virus (HBV) infectionpresenting with features suggestive of HBV-associated nephropathy. A renal biopsy specimen suggested a mesangioproliferative glomerulonephritis with a full-house pattern on immunoflourescence consistent with a diagnosis of diffuse lupus nephritis. Glomerular HbeAg and HbsAg antigens were not detectable by immunofluorescence. Antiviral therapy was instituted to suppressviral replication, thereby leading to clinical and virological remission, including that of the glomerulonephritis, without the need for additional immunosuppressant therapy. This case depicts the uniqueness of the presentation of the two conditionsmimicking each other, the strategy adopted to prevent the activation of viral replication and the achievement of clinical remission.

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References

  1. Lai FM, To KF, Wang AYM, Choi PCL, Szeto CC, Li PKT et al. Hepatitis B virus–related nephropathy and lupus nephritis: morphologic similarities of two clinical entities, Mod Pathol 2000;13:166–172.
  2. Lai KN, Lai FM, Chan KW, Chow CB, Tong KL, Vallance-Owen J. The clinico-pathologic features of hepatitis B virus-associated glomerulonephritis, Q J Med 1987;63:323–333.
  3. Ho V, Mclean A, Terry S. Severe systemic lupus erythematosus induced by antiviral treatment for hepatitis C, J Clin Rheumatol 2008;14:166–168.
  4. Abbott IJ, Chang CC, Skinner MJ, Street A, Perry G, McLean C et al. Development and management of systemic lupus erythematosus in an HIV-infected man with hepatitis C and B co-infection following interferon therapy: a case report, J Med Case Rep 2009;3:7289.
  5. Bhimma R, Coovadia HM. Hepatitis B virus-associated nephropathy, Am J Nephrol 2004;24:198–211.
  6. Lai FM, Lai KN, Lee JC, Hom BL. Hepatitis B virus-related glomerulopathy in patients with systemic lupus erythematosus, Am J Clin Pathol 1987;88:412–420.

Published

2014-04-15

Issue

Vol. 1 No. 1 (2014)

How to Cite

1.
Aggarwal A, Agarwal MP, Rajpal S, Batra VV, Sahu AK. Chronic Active Hepatitis B with HBV-Associated Nephropathy: Close Resemblance to Lupus Nephritis. EJCRIM [Internet]. 2014 Apr. 15 [cited 2026 Nov. 3];1(1). Available from: https://ejcrim.com/index.php/ejcrim/article/view/40

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