DOI: 10.12890/2023_003977
Deep vein thrombosis revealing a "silent" coeliac disease
Authors
sofiairmiranda@gmail.com
Keywords
Venous thromboembolism, coeliac diseaseAbstract
Introduction: We present a clinical case of a 45-year-old man with recurrent deep vein thrombosis (DVT) and multiple hospital admissions due to severe infectious conditions. A newfound hypoalbuminemia raised the suspicion of a protein-losing condition, with an upper endoscopy revealing lesions at the D2 level compatible with coeliac sprue and HLA typing positive for both DQ-2 and DQ-8.
Methods: A gluten free diet was started and apixaban was suspended.
Results: No new complications were reported.
Discussion: Multiple mechanisms are believed to be behind the association between DVT and coeliac disease. However, to this date, no consensus exists regarding the ideal duration of anticoagulation.
References
- Pantic N, Pantic I, Jevtic D, Mogulla V, Oluic S, Durdevic M et al. Celiac disease and thrombotic events: A systematic review of published cases. Nutrients 2022;14:2162.
- Fousekis FS, Beka ET, Mitselos IV, Milionis H, Christodoulou DK. Thromboembolic complications and cardiovascular events associated with celiac disease. Ir J Med Sci 2021;190:133–141.
- Dumic I, Martin S, Salfiti N, Watson R, Alempijevic T. Deep vein thrombosis and bilateral pulmonary embolism revealing silent celiac disease: Case report and review of literature. Case Rep Gastrointest Med 2017;2017:5236918.
- Alhosain D, Kouba L. Concurrent cerebral arterial and venous sinus thrombosis revealing celiac disease—A case report and literature review. BMC Gastroenterol 2020;20:327.
- Grigg AP. Deep venous thrombosis as the presenting feature in a patient with celiac disease and homocysteinemia. Aust N Z J Med 1999;29:566–7.