DOI: 10.12890/2023_003924

Acyclovir-induced glomerulonephritis in a 40-year-old woman without medical history: a case report

Authors

  • Marie-Justine Desrumaux Department of Nephrology, AZ Glorieux, Ronse, Belgium
  • Elien Mahieu Department of Nephrology, AZ Glorieux, Ronse, Belgium
  • Céline Vanfraechem Department of Nephrology, AZ Glorieux, Ronse, Belgium

mariejustine.desrumaux@student.kuleuven.be

Keywords

Acyclovir, encephalopathy, acute kidney disease

Abstract

Well-known side effects of acyclovir are nephrotoxicity and neurotoxicity. We present a 49-year-old woman without pre-existing renal failure, with an acute kidney injury and encephalopathy. Since there was a clear correlation with the intake of acyclovir and the course of illness, findings were attributed to the antiviral agent. Urinalysis showed a proteinuria in nephrotic ranges, which is not described in the currently known causes of acyclovir-induced renal failure. We postulate the hypothesis of a nephritis with podocyte damage induced by acyclovir or, more likely, by an acyclovir metabolite.

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References

  1. Perazella MA. Crystal-induced acute renal failure. Am J Med 1999;106:459–465.
  2. Sawyer MH, Webb DE, Balow JE, Straus SE. Acyclovir-induced renal failure. Clinical course and histology. Am J Med 1988;84:1067–1071.
  3. De Deyne S, De la Gastine B, Gras G, Dargère S, Verdon R, Coquerel A. Acute renal failure with acyclovir in a 42-year-old patient without previous renal dysfunction. Rev Med Interne 2006;27:892–894.
  4. Kenzaka T, Sugimoto K, Goda K, Akita H. Acute kidney injury and acyclovir-associated encephalopathy after administration of valacyclovir in an elderly person with normal renal function: a case report and literature review. Medicine (Baltimore) 2021;100:e26147
  5. Gunness P, Aleksa K, Bend J, Koren G. Acyclovir-induced nephrotoxicity: the role of the acyclovir aldehyde metabolite. Transl Res 2011;158:290–301.

Published

2023-09-15

Issue

Vol. 10 No. 10 (2023)

How to Cite

1.
Desrumaux M-J, Mahieu E, Vanfraechem C. Acyclovir-induced glomerulonephritis in a 40-year-old woman without medical history: a case report. EJCRIM [Internet]. 2023 Sep. 15 [cited 2026 Nov. 3];10(10). Available from: https://ejcrim.com/index.php/ejcrim/article/view/3924

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