DOI: 10.12890/2022_003540

Overlapping Presentations of HELLP Syndrome and COVID-19: A Case Report

Authors

  • Leila C Tou Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA
  • Andrew A Wang Charles E. Schmidt College of Medicine, Florida Atlantic University, Boca Raton, FL, USA
  • Taha A Siddiqui Philadelphia College of Osteopathic Medicine, NW, Suwanee, USA
  • Michael Mamone Department of Internal Medicine, Florida Atlantic University, Boca Raton, FL, USA

leilac.1416@gmail.com

Keywords

COVID-19, SARS-CoV-2, preeclampsia, HELLP, gestational hypertension

Abstract

Introduction: Hemolysis, elevated liver enzymes, low platelet count (HELLP) syndrome is a leading cause of maternal mortality. The emergence of Coronavirus disease 2019 (COVID-19) has led to challenges in diagnosing HELLP syndrome due to overlapping clinical and laboratory presentations. We report a case of HELLP syndrome complicated by COVID-19 infection.

Case Description: An otherwise healthy pregnant 31-year-old female presented with fever, myalgia, and headache. She was found to be COVID-positive with laboratory signs of HELLP syndrome. Symptoms and laboratory findings trended toward normal post-partum confirming the diagnosis of HELLP syndrome.

Discussion: A prompt diagnosis of HELLP syndrome is essential to avoid maternal and fetal complications. Clinicians should be aware of the similarities in presentation between HELLP syndrome and COVID-19 for timely diagnosis and treatment.

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References

  1. Haram K, Svendsen E, Abildgaard U. The HELLP syndrome: clinical issues and management. A review. BMC Pregnancy Childbirth 2009;9(1):8. doi:10.1186/1471-2393-9-8
  2. Long R, Wu D, Lin X, Lv D, Wang R, Jin L, et al. COVID-19 and pregnancy: a case study. Glob Chall 2021;5(8):2000074. doi:10.1002/gch2.202000074
  3. Coronado-Arroyo JC, Concepción-Zavaleta MJ, Zavaleta-Gutiérrez FE, Concepción-Urteaga LA. Is COVID-19 a risk factor for severe preeclampsia? Hospital experience in a developing country. Eur J Obstet Gynecol Reprod Biol 2021;256:502–503. doi:10.1016/j.ejogrb.2020.09.020
  4. Futterman I, Toaff M, Navi L, Clare CA. COVID-19 and HELLP: overlapping clinical pictures in two gravid patients. AJP Rep 2020;10(02):e179–e182. doi:10.1055/s-0040-1712978
  5. Arslan E. COVID-19: a cause of HELLP syndrome? A case report. IJWH 2022;14:617–623. doi:10.2147/IJWH.S362877
  6. Shanes ED, Mithal LB, Otero S, Azad HA, Miller ES, Goldstein JA. Placental pathology in COVID-19. Am J Clin Pathol 2020;154(1):23–32. doi:10.1093/ajcp/aqaa089
  7. Sharps MC, Hayes DJL, Lee S, Zou Z, Brady CA, Almoghrabi Y, et al. A structured review of placental morphology and histopathological lesions associated with SARS-CoV-2 infection. Placenta 2020;101:13–29. doi:10.1016/j.placenta.2020.08.018
  8. Ronnje L, Länsberg JK, Vikhareva O, Hansson SR, Herbst A, Zaigham M. Complicated COVID-19 in pregnancy: a case report with severe liver and coagulation dysfunction promptly improved by delivery. BMC Pregnancy Childbirth 2020;20(1):511. doi:10.1186/s12884-020-03172-8
  9. Popovici D, Crauciuc E, Tiperciuc R-A, Buznea G-A, Akad M, Hurjui L, et al. HELLP syndrome complicated with ascites during third trimester of pregnancy – therapeutic management. Maedica (Bucur) 2018;13(4):331–335. doi:10.26574/maedica.2018.13.4.331
  10. Figueras F, Llurba E, Martinez-Portilla R, Mora J, Crispi F, Gratacos E. COVID-19 causing HELLP-like syndrome in pregnancy and role of angiogenic factors for differential diagnosis. medRxiv 2020. Published online 11 July 2020. doi:10.1101/2020.07.10.20133801

Published

2022-09-07

Issue

Vol. 9 No. 9 (2022)

Categories

How to Cite

1.
Tou L, Wang A, Siddiqui T, Mamone M. Overlapping Presentations of HELLP Syndrome and COVID-19: A Case Report. EJCRIM [Internet]. 2022 Sep. 7 [cited 2026 Nov. 3];9(9). Available from: https://ejcrim.com/index.php/ejcrim/article/view/3540