Behçet's Disease-related Budd–Chiari Syndrome Successfully Managed with anti-TNF Antibody: A Case Report and Review of the Literature

Authors

• Enes Erul Department of Internal Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey
• Gullu Sandal Uzun Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey
• Deniz Koksal Department of Pulmonary Diseases, Faculty of Medicine, Hacettepe University, Ankara, Turkey
• Onur Keskin Department of Gastroenterology, Faculty of Medicine, Hacettepe University, Ankara, Turkey
• Serkan Uysal Department of Thoracic Surgery, Faculty of Medicine, Hacettepe University, Ankara, Turkey
• Ahmet Cagkan Inkaya Department of Infectious Diseases, Faculty of Medicine, Hacettepe University, Ankara, Turkey
• Umut Kalyoncu Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Hacettepe University, Ankara, Turkey

eneserul@hotmail.com

Keywords

Abstract

Behçet's disease (BD) is multisystemic vasculitis with heterogeneous clinical manifestations. We describe the case of a 26-year-old man who presented with Budd–Chiari syndrome (BCS) related to BD. The patient received infliximab (IFX) due to the severity of vascular involvement. Subsequently, after IFX therapy, hospital-acquired pneumonia, trapped lung, and fungal infection of the lung and central nervous system developed as complications. The patient benefited from a second course of IFX and clinical remission was achieved following early identification and treatment of complications. Data on the presentation and prognosis of BCS related to BD are extremely limited. Our case report supports the growing evidence that anti-TNF antibody is a promising treatment for BD-related BCS.