DOI: 10.12890/2022_003209
Invasive Pulmonary Aspergillosis after COVID-19 Pneumonia
Authors
filipa.dc@hotmail.com
Keywords
COVID-19, pulmonary aspergillosis, Aspergillus nigerAbstract
COVID-19 emerged in China in late 2019 and quickly spread worldwide. The severe immunomodulation and depletion of lymphocytes caused by the virus and its therapy led to an increase in the incidence of superinfections. COVID-19-associated pulmonary aspergillosis (CAPA) is a new entity with increasing incidence and high associated mortality.
We present the case of a 68-year-old patient admitted to our ward after recovering from severe COVID-19 pneumonia. Due to worsening of her clinical condition, chest computed tomography was performed and a lung abscess was documented with the identification of Aspergillus niger. Despite therapy with voriconazole, the patient’s condition deteriorated, culminating in her death.
COVID-19 emerged in China in late 2019 and quickly spread worldwide. The severe immunomodulation and depletion of lymphocytes caused by the virus and its therapy led to an increase in the incidence of superinfections. COVID-19-associated pulmonary aspergillosis (CAPA) is a new entity with increasing incidence and high associated mortality.
We present the case of a 68-year-old patient admitted to our ward after recovering from severe COVID-19 pneumonia. Due to worsening of her clinical condition, chest computed tomography was performed and a lung abscess was documented with the identification of Aspergillus niger. Despite therapy with voriconazole, the patient’s condition deteriorated, culminating in her death.
References
- Machado M, Valerio M, Álvarez-Uría A, Olmedo M, Veintimilla C, Padilla B, et al. Invasive pulmonary aspergillosis in the COVID-19 era: an expected new entity. Mycoses 2021 Feb;64(2):132–143.
- Dewi IM, Janssen NA, Rosati D, Bruno M, Netea MG, Brüggemann RJ, et al. Invasive pulmonary aspergillosis associated with viral pneumonitis. Curr Opin Microbiol 2021 Aug;62:21–27.
- Lai C-C, Yu W-L. COVID-19 associated with pulmonary aspergillosis: a literature review. J Microbiol Immunol Infect 2021 Feb;54(1):46–53.
- El-Baba F, Gao Y, Soubani AO. Pulmonary aspergillosis: what the generalist needs to know. Am J Med 2020 Jun;133(6):668–674.
- Wauters J, Lamoth F, Rijnders BJ, Calandra T. Invasive pulmonary aspergillosis goes viral again? Am J Respir Crit Care Med 2021 Feb 1;203(3):275–277.