DOI: 10.12890/2022_003115

A Severe Case of Molluscum Contagiosum Immune Reconstitution Inflammatory Syndrome in a Patient with Human Immunodeficiency Virus

Authors

  • Nida Siddiqui Dept. of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
  • Brett Stephen Mansfield Dept. of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa
  • Nine-Paula Olmesdahl Division of Anatomical Pathology, Dept. of Pathology, National Health Laboratory Service and University of the Witwatersrand, Johannesburg, South Africa
  • Peter Swart Division of Anatomical Pathology, Dept. of Pathology, National Health Laboratory Service and University of the Witwatersrand, Johannesburg, South Africa
  • Jeremy Nel Division of Infectious Diseases, Dept. of Internal Medicine, School of Clinical Medicine, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa

nidamishraz@gmail.com

Keywords

Immune reconstitution inflammatory syndrome, molluscum contagiosum, human immunodeficiency virus, MC-IRIS

Abstract

Paradoxical immune reconstitution inflammatory syndrome (IRIS) in human immunodeficiency virus (HIV)-positive patients initiating antiretroviral treatment (ART) is caused by restored immunity to specific antigens, resulting in worsening of a pre-existing infection. Molluscum contagiosum (MC) is commonly noted in HIV-positive individuals but ART alone is usually sufficient to bring about resolution. We present a rare case of severe MC-IRIS that worsened despite immune reconstitution.

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References

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Published

2022-01-11

Issue

Vol. 9 No. 1 (2022)

How to Cite

1.
Siddiqui N, Mansfield BS, Olmesdahl N-P, Swart P, Nel J. A Severe Case of Molluscum Contagiosum Immune Reconstitution Inflammatory Syndrome in a Patient with Human Immunodeficiency Virus. EJCRIM [Internet]. 2022 Jan. 11 [cited 2026 Nov. 3];9(1). Available from: https://ejcrim.com/index.php/ejcrim/article/view/3115

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