DOI: 10.12890/2022_003107

Primary Central Nervous System Lymphoma with Exclusive Leptomeningeal Involvement: The Diagnostic Challenge of a Rare Presentation of an Uncommon Disease

Authors

  • Miguel Santos Department of Internal Medicine, Centro Hospitalar de Leiria, Leiria, Portugal
  • Tatiana Pires Department of Internal Medicine, Centro Hospitalar de Leiria, Leiria, Portugal
  • Ana Rodrigues Department of Internal Medicine, Centro Hospitalar de Leiria, Leiria, Portugal
  • Adriana Bandeira Department of Internal Medicine, Centro Hospitalar de Leiria, Leiria, Portugal
  • Ana Albuquerque Department of Internal Medicine, Centro Hospitalar de Leiria, Leiria, Portugal
  • Flávia Santos Department of Internal Medicine, Centro Hospitalar de Leiria, Leiria, Portugal
  • Miriam Magalhães Department of Internal Medicine, Centro Hospitalar de Leiria, Leiria, Portugal
  • Maria Jesus Banza Department of Internal Medicine, Centro Hospitalar de Leiria, Leiria, Portugal

migonsa@gmail.com

Keywords

Primary central nervous system lymphoma, leptomeningeal lymphoma

Abstract

Primary central nervous system lymphoma (PCNSL) is a rare and aggressive extra-nodal non-Hodgkin lymphoma (NHL). It must be confined to the brain, eyes, spinal cord or leptomeninges without systemic involvement at the time of diagnosis. Disease confined to the cerebrospinal fluid (CSF) is a rare form of presentation and poses a particular diagnostic challenge.
We present the case of an 82-year-old man admitted to hospital because of an acute confusional state, later revealed to be due to PCNSL with exclusive leptomeningeal involvement. The diagnostic process was further impaired (or, perhaps, aided?) by the onset of a COVID-19 outbreak on the ward.

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References

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Published

2022-01-27

Issue

Vol. 9 No. 1 (2022)

How to Cite

1.
Santos M, Pires T, Rodrigues A, Bandeira A, Albuquerque A, Santos F, et al. Primary Central Nervous System Lymphoma with Exclusive Leptomeningeal Involvement: The Diagnostic Challenge of a Rare Presentation of an Uncommon Disease. EJCRIM [Internet]. 2022 Jan. 27 [cited 2026 Nov. 3];9(1). Available from: https://ejcrim.com/index.php/ejcrim/article/view/3107

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