DOI: 10.12890/2021_003021

Nannizziopsis Immune Reconstitution Inflammatory Syndrome in a Patient with HIV: First Reported Case

Authors

  • Yi Zhao Imperial College London School of Medicine, London, UK
  • Mikhail Nozdrin Department of Infectious Diseases, Imperial College London, London, UK
  • Alessia Dalla Pria Department of Infectious Diseases, Imperial College London, London, UK; Department of HIV Medicine, Chelsea and Westminster Hospital, London, UK
  • Margherita Bracchi Department of HIV Medicine, Chelsea and Westminster Hospital, London, UK

margherita.bracchi@nhs.net

Keywords

HIV, immune reconstitution inflammatory syndrome, IRIS, Nannizziopsis

Abstract

We describe the case of a 35-year-old HIV-positive male of African origin diagnosed with neurotoxoplasmosis and a Nannizziopsis spp. cavitating pulmonary lesion unmasking immune reconstitution inflammatory syndrome (IRIS).

The patient presented with headache, left hemiparesis and confusion. MRI of the brain showed two space-occupying lesions in the right basal ganglia and left parietal lobe typical for neurotoxoplasmosis. The patient tested positive for HIV and had advanced CD4 lymphopenia. After commencement of antiretroviral treatment, a CT scan of the chest showed a cavitating lesion in the right upper lobe. The diagnosis of Nannizziopsis spp. fungal infection was confirmed by DNA sequencing on a bronchial wash sample. The patient achieved complete recovery with antiretroviral therapy, standard neurotoxoplasmosis treatment and antifungal treatment with voriconazole for 12 weeks.

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References

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Published

2021-11-23

Issue

Vol. 8 No. 11 (2021)

How to Cite

1.
Zhao Y, Nozdrin M, Dalla Pria A, Bracchi M. Nannizziopsis Immune Reconstitution Inflammatory Syndrome in a Patient with HIV: First Reported Case. EJCRIM [Internet]. 2021 Nov. 23 [cited 2026 Nov. 4];8(11). Available from: https://ejcrim.com/index.php/ejcrim/article/view/3021