DOI: 10.12890/2021_002981
IgG4-Related Disease Affecting Testicle and Myelodysplastic Syndrome: Just a Coincidence?
Authors
carlaalvarezgonzalez@hotmail.com
Keywords
Immunoglobulin G4-related disease, IgG4-RD, myelodysplastic syndrome, testicleAbstract
Immunoglobulin G4-related disease (IgG4-RD) is progressive immune-mediated fibrotic condition characterised by a tendency to form tumefactive lesions in different organs and by elevated IgG4 serum concentrations. Urological manifestations are rare and normally occur together with other systemic affections. Myelodysplastic syndromes (MDS) are hematopoietic stem cell neoplasms, with different subtypes based on the type of blood cells involved. MDS can be associated with other pathologies or medical treatments. We present an uncommon case of testicular manifestation associated with myelodysplastic syndrome here.
References
- Perugino CA, Stone JH. IgG4-related disease: an update on pathophysiology and implications for clinical care. Nat Rev Rheumatol 2020;16(12):702–714.
- de Buy Wenniger LM, Scheltema JM, Verheij J, Beuers U. Testicular inflammation as a new manifestation of IgG4-associated disease. Urology 2013;82(2):e15–16.
- Tokura Y, Kobayashi M, Kusakabe T, Kamai T. Case of hydrocele testis caused by vaginalitis, a rare manifestation of immunoglobulin G4-related disease. Int J Urol 2017;24(10):771–773.
- Lal J, Bhat S, Doddamani S, Devi L. Isolated testicular immunoglobulin G4-related disease: a mimicker of malignancy. Indian J Urol 2016;32(4):326–328.
- Tabata R, Tabata C, Okamoto T, Omori K, Terada M, Nagai T. Autoimmune pancreatitis associated with myelodysplastic syndrome. Int Arch Allergy Immunol 2010;151(2):168–172.
- Matsumoto N, Hishikawa N, Ikegami K, Sato K, Omote Y, Takemoto M, et al. A unique case of encephalopathy with an elevated IgG-4 and extremely high interleukin-6 level and delayed myelodysplastic syndrome. Intern Med 2021;60(13):2125–2128.