DOI: 10.12890/2015_000245

Hyperinsulinaemic hypoglycaemia - a diagnostic challenge. A report of two atypical cases.

Authors

  • Renata Baronaite Hansen Department of Medical Endocrinology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
  • Ulla Feldt Rasmussen Department of Medical Endocrinology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
  • Åse Krogh Rasmussen Department of Medical Endocrinology, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
  • Carsten Palnaes Hansen Department of Gastrointestinal Surgery & Transplantation, Neuroendocrine Tumour Center of Excellence, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark
  • Ulrich Knigge Department of Gastrointestinal Surgery & Transplantation, Neuroendocrine Tumour Center of Excellence, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark

renatabhansen@gmail.com

Keywords

Hyperinsulinaemic hypoglycaemia, insulinoma, glucagonoma, malignant insulinoma, nesidioblastosis.

Abstract

Objectives: The authors describe 2 atypical cases of patients with hypoglycaemia, suspected for insulinoma.

Methods: The 2 reports are accompanied by a concise review of the literature.

Results: Patient 1 had a distal pancreatectomy performed for suspected insulinoma, and was diagnosed with a glucagonoma and beta-cell hyperplasia (nesidioblastosis). To the authors’s knowledge, co-existing glucagonoma and nesidioblastosis had not been previously reported.
Patient 2 was diagnosed with a benign insulinoma and 5 years later with metastatic disease.

Conclusion: The authors conclude that insulinomas are rare entities which often present a diagnostic and therapeutic challenge. In such cases, patient referral to tertiary multidisciplinary centers is recommended.

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References

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Published

2015-07-17

Issue

Vol. 2 No. 4 (2015)

How to Cite

1.
Baronaite Hansen R, Feldt Rasmussen U, Krogh Rasmussen Å, Palnaes Hansen C, Knigge U. Hyperinsulinaemic hypoglycaemia - a diagnostic challenge. A report of two atypical cases. EJCRIM [Internet]. 2015 Jul. 17 [cited 2026 Nov. 3];2(4). Available from: https://ejcrim.com/index.php/ejcrim/article/view/245