DOI: 10.12890/2021_002215

Ceftriaxone-induced Agranulocytosis

Authors

  • Lénio Couto Hospital de Santo Espírito da Ilha Terceira, Angra do Heroísmo, Portugal
  • André Goulart Hospital de Santo Espírito da Ilha Terceira, Angra do Heroísmo, Portugal
  • Ivone Valadão Hospital de Santo Espírito da Ilha Terceira, Angra do Heroísmo, Portugal
  • Magda Garça Hospital de Santo Espírito da Ilha Terceira, Angra do Heroísmo, Portugal
  • Maria Beatriz Santos Hospital de Santo Espírito da Ilha Terceira, Angra do Heroísmo, Portugal
  • Pedro Cota Hospital de Santo Espírito da Ilha Terceira, Angra do Heroísmo, Portugal
  • Carolina Teixeira Hospital de Santo Espírito da Ilha Terceira, Angra do Heroísmo, Portugal

leniopcouto@gmail.com

Keywords

Ceftriaxone, neutropenia, drug-induced agranulocytosis

Abstract

Ceftriaxone is a widely used antibiotic regarded as safe and effective. Drug-induced agranulocytosis is a life-threatening adverse reaction and few reports related to ceftriaxone were found in a review of the literature. The authors present a case of ceftriaxone-induced agranulocytosis, in which a brain abscess was diagnosed and ceftriaxone was commenced. Neutropenic fever occurred on the 29th day of therapy with a cumulative dose of 116 g ceftriaxone and a neutrophil nadir of 0.1×109/l. Ceftriaxone was withheld, filgrastim was administered for 3 days and neutrophil normalization was achieved. Although rare, ceftriaxone-induced agranulocytosis may occur in patients on a long course of ceftriaxone therapy. Prompt recognition and drug withdrawal are required.

View the entire article

Downloads

References

  1. Sileshi A, Tenna A, Feyissa M, Shibeshi W. Evaluation of ceftriaxone utilization in medical and emergency wards of Tikur Anbessa specialized hospital: a prospective cross-sectional study. BMC Pharmacol Toxicol 2016;17:7.
  2. Andersohn F, Konzen C, Garbe E. Systematic review: agranulocytosis induced by nonchemotherapy drugs. Ann Intern Med 2017;146(9):657–665.
  3. Mintzer DM, Billet SN, Chmielewski L. Drug-induced hematologic syndromes. Adv Hematol 2009;2009:495863.
  4. Andrès E, Federici L, Weitten T, Vogel T, Alt M. Recognition and management of drug-induced blood cytopenias: the example of drug-induced acute neutropenia and agranulocytosis. Expert Opin Drug Saf 2008;7(4):481–489.
  5. Neftel KA, Hauser SP, Müller MR. Inhibition of granulopoiesis in vivo and in vitro by ?-lactam antibiotics. J Infect Dis 1985;152(1):90–98.
  6. Naranjo CA, Busto U, Sellers EM, Sandor P, Ruiz I, Roberts EA, et al. A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther 1981;30(2):239–245

Published

2021-01-08

Issue

Vol. 8 No. 1 (2021)

How to Cite

1.
Couto L, Goulart A, Valadão I, Garça M, Santos MB, Cota P, et al. Ceftriaxone-induced Agranulocytosis . EJCRIM [Internet]. 2021 Jan. 8 [cited 2026 Nov. 3];8(1). Available from: https://ejcrim.com/index.php/ejcrim/article/view/2215

Most read articles by the same author(s)