DOI: 10.12890/2020_001818

Multiple Endocrine Neoplasia or Accidental Association?

Authors

  • Georgiana Cristina Taujan Endocrinology Department, Centre Hospitalier Universitaire Brugmann, Brussels, Belgium
  • Felicia Baleanu Endocrinology Department, Centre Hospitalier Universitaire Brugmann, Brussels, Belgium
  • Linda Spinato Oto-Rhino-Laryngology Department, Centre Hospitalier Universitaire Brugmann, Brussels, Belgium
  • Ruth Duttmann Anatomic Pathology Department, Centre Hospitalier Universitaire Brugmann, Brussels, Belgium
  • Rafik Karmali Endocrinology Department, Centre Hospitalier Universitaire Brugmann, Brussels, Belgium
  • Laura Iconaru Endocrinology Department, Centre Hospitalier Universitaire Brugmann, Brussels, Belgium

georgianacristina.taujan@chu-brugmann.be

Keywords

Pheochromocytoma, hyperparathyroidism, papillary thyroid carcinoma

Abstract

Pheochromocytoma, papillary thyroid carcinoma and hyperparathyroidism have rarely been reported together. Whether this association is coincidental or results from an unknown genetic predisposition is difficult to ascertain.
We present the case of a patient who was diagnosed with pheochromocytoma, bilateral papillary thyroid carcinoma and parathyroid hyperplasia with primary hyperparathyroidism. A genetic mutation was hypothesized as the connection between these lesions. Previously described mutations were explored.

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References

  1. Yang JH, Bae SJ, Park S, Park HK, Jung HS, Chung JH, et al. Bilateral pheochromocytoma associated with paraganglioma and papillary thyroid carcinoma: report of an unusual case. Endocr J 2007;54(2):227–231.
  2. Gelato MC, Vassalotti J. Insulin-like growth factor-II: possible local growth factor in pheochromocytoma. J Clin Endocrinol Metab 1990;71:1168–1174.
  3. Miccoli P, Minuto MN, Galleri D, D'Agostino V, Basolo F, Antonangeli L, et al. Incidental thyroid carcinoma in a large series of consecutive patients operated on for benign thyroid disease. Anz J Surg 2006;76(3):123–126.
  4. Nilsson IL, Zedenius J, Yin L, Anders E. The association between primary hyperparathyroidism and malignancy: nationwide cohort analysis on cancer incidence after parathyroidectomy. Endocr Relat Cancer 2007;14:135–140.
  5. Goswami S, Ghosh S. Hyperparathyroidism: cancer and mortality. Indian J Endocrinol Metab 2012;16(Suppl 2):S217–220.
  6. Rivera M, Ricarte-Filho J, Knauf J, Shaha A, Tuttle M, Fagin J, et al. Molecular genotyping of papillary thyroid carcinoma follicular variant according to its histological subtypes (encapsulated vs infiltrative) reveals distinct BRAF and RAS mutation patterns. Mod Pathol 2010;23(9):1191–1200.

Published

2020-08-10

Issue

Vol. 7 No. 11 (2020)

How to Cite

1.
Taujan GC, Baleanu F, Spinato L, Duttmann R, Karmali R, Iconaru L. Multiple Endocrine Neoplasia or Accidental Association? EJCRIM [Internet]. 2020 Aug. 10 [cited 2026 Nov. 4];7(11). Available from: https://ejcrim.com/index.php/ejcrim/article/view/1818

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