DOI: 10.12890/2014_000017
Breast Carcinoma with Choriocarcinomatous Differentiation: A Rare Case
Authors
oguzarzu@yahoo.com
Abstract
Objectives: Breast carcinoma with choriocarcinomatous differentiation is a rare entity, generally presenting with high-grade disease and an aggressive clinicalcourse with overall survival of less than a year.
Case: A 69-year-old woman with a diagnosis of pT1N0M0 invasive ductal carcinoma with choriocarcinomatous differentiation received six cycles ofadjuvant chemotherapy and is still disease free on the 23rd month after diagnosis, showing a better prognosis than most other cases reported in theliterature.
Conclusion: The reason for the poor prognosis for this type of breast carcinoma remains unclear. Standard chemotherapeutic agents administered for breastcarcinoma may be used for choriocarcinomatous differentiation.
References
- Dennis PM, Turner AG. Primary choriocarcinoma of the bladder evolving from a transitional call carcinoma, J Clin Pathol 1984;37:503-505.
- McKechnie JC, Fechner RE. Choriocarcinoma and adenocarcinoma of the esophagus with gonadotropin secretion, Cancer 1971;27:694-702.
- Park CH, Reid JD. Adenocarcinoma of the colon with choriocarcinoma in its metastases, Cancer 1980;46:570-575.
- Saigo PE, Rosen PP. Mammary carcinoma with ‘choriocarcinomatous’ features, Am J Surg Pathol 1981;5:773-778.
- Murata T, Ihara S, Nakayama T, Nakagawa SI, Higashiguchi T, Imai T et al. Breast cancer with choriocarcinomatous features: A case report with cytopathologic details, Pathol Int 1999;49:816-819.
- Filho OG, Miiji LNO, Vainchenker M, Gordan AN. Breast cancer with choriocarcinomatous and neuroendocrine features, Sao Paulo Med J 2001;119:154-155.
- Erhan Y, Ozdemir N, Zekioglu O, Nart D, Ciris M. Breast carcinomas with choriocarcinomatous features: case reports and review of the literature, Breast J 2002;8:244-248.
- Mohammadi A, Rosa M. Carcinoma of the breast with choriocarcinomatous features, Arch Pathol Lab Med 2011;135:1097-1100.
- Rosen PP. Rosen’s breast pathology. 3rd ed. Philedelphia , PA:Lippicott Williams& Wilkins;2008.
- Choi HJ, Park IA. Fine needle aspiration cytology of metastatic choriocarcinoma presenting as a breast lump. A case report, Acta Cytol 2004;48:91-94.
- Fowler CA, Nicholson S, Lott M, Barley V. Choriocarcinoma presenting as a breast lump, Eur J Surg Oncol. 1995;21:576-578.
- Resetkova E, Sahin A, Ayala AG, Sneige N. Breast carcinoma with choriocarcinomatous features, Ann Diagn Pathol 2004;8:74-79.
- Canbay E, Bozkurt B, Ergul G, Agrali G, Cengiz O. Breast carcinoma with choriocarcinomatous features,Breast J 2010;16:202-203.
- Akbulut M, Zekioglu O, Ozdemir N, Kapkac M. Fine needle aspiration cytology of mammary carcinoma with choriocarcinomatous features: a report of 2 cases, Acta Cytol 2008;52:99-104.
- Siddiqui NH, Cabay RJ, Salem F. Fine needle aspiration biopsy of a case of breast carcinoma with choriocarcinomatous features, Diagn Cytopathol 2006;34:694-697.
- Green DM. Mucoid carcinoma of the breast with choriocarcinoma in its metastases, Histopathology 1990;16:504-506.