DOI: 10.12890/2014_000146
Paraneoplastic Polymyalgia Rheumatica as Manifestation of a Pancreatic Neuroendocrine Tumour
Authors
lscasa@sapo.pt
Keywords
Paraneoplastic syndrome, polymyalgia rheumatica, cancerAbstract
Autoimmune diseases may present as paraneoplastic syndrome. This is especially recognized in the case of polymyositis/dermatomyositis, but is less common in polymyalgia rheumatica. The authors describe the case of a 73-year-old man who presented with pain and stiffness of the scapular and pelvic girdles associated with asthenia lasting for a few weeks. The presence of therapeutic resistance and other atypical features directed the investigation towards the search of an occult malignancy. Patient evaluation revealed a pancreatic neuroendocrine tumour. After surgical treatment of the underlying neoplasia, the patient recovered fully with resolution of the rheumatic disease.
References
- Fam AG. Paraneoplastic rheumatic syndrome, Baillieres Best Pract Res Clin Rheumatol 2000;14:515–533.
- Milan SA, Yeo CJ. Neuroendocrine tumors of the pancreas, Curr Opin Oncol 2012;24:46–55.
- Dasgupta B, Cimmino M, Kremers H, Schmidt W, Schirmer M, Salvarani C et al. 2012 Provisional classification criteria for polymyalgia rheumatica: a European League Against Rheumatism/American College of Rheumatology collaborative initiative, Arthritis Rheum 2012;64:943–954.
- Cocquempot K, Defuentes G, Duron-Martineau S, Berets O, Vaylet F, Margery J. Polymyalgia rheumatica revealing a lung cancer, Rev Mal Respir 2013;30:67–70.
- Kehler T, Curković B. Polymyalgia rheumatica and colon malignancy: case report. Clin Rheumatol 2006;25:764–765.
- Kaltsas G, Androulakis II, Herder WW, Grossman AB. Paraneoplastic syndromes secondary to neuroendocrine tumours, Endocr Relat Cancer 2010;17:R173–R193.