Invasive Pneumococcal Disease Associated with Fanconi-Like Syndrome

Authors

• Jade Xiao Jue Soh Department of General Medicine, Sengkang General Hospital, Singapore
• Raymond Kai Heng Goh Department of General Medicine, Sengkang General Hospital, Singapore
• Shuwei Zheng Department of General Medicine, Sengkang General Hospital, Singapore

jade.soh.x.j@singhealth.com.sg

Keywords

Abstract

Acquired causes of Fanconi syndrome in adults are usually due to drugs, toxins or paraproteinaemias. Infectious causes are rarely described. We report a case of invasive pneumococcal disease in a patient who developed a Fanconi-like syndrome during the course of her illness. This patient presented with multiple electrolyte derangements consisting predominantly of hypokalaemia, hypomagnesaemia and hypophosphataemia during hospitalization for invasive pneumococcal disease with possible Austrian syndrome. Further evaluation revealed significant urinary losses of these electrolytes, uric acid and ?2-microglobulin. Together with evidence of hypouricaemia, this is suggestive of proximal renal tubulopathy, and hence a Fanconi-like syndrome. The patient’s clinical condition and biochemical anomalies improved following pneumococcus treatment.