DOI: 10.12890/2014_000123

A Rare Manifestation of Crohn's Disease: Sinonasal Granulomatosis. Report of a Case and Review of Literature

Authors

  • Lilia Baili Department of Internal Medicine, Habib Thameur Hospital, University El Manar, Tunis
  • Imène Rachdi Department of Internal Medicine, Habib Thameur Hospital, University El Manar, Tunis
  • Fatma Daoud Department of Internal Medicine, Habib Thameur Hospital, University El Manar, Tunis
  • Zohra Aydi Department of Internal Medicine, Habib Thameur Hospital, University El Manar, Tunis
  • Basma Ben Dhaou Department of Internal Medicine, Habib Thameur Hospital, University El Manar, Tunis
  • Samir Kochbati Department of Internal Medicine, Habib Thameur Hospital, University El Manar, Tunis
  • Fatma Boussema Department of Internal Medicine, Habib Thameur Hospital, University El Manar, Tunis

rachdi.imene14@gmail.com

Abstract

Crohn’s disease is a granulomatous in?ammatory bowel disease. Its pathologic ?ndings include non-contiguous chronic in?ammation and non-caseating granulomas, sometimes with extra-intestinal localizations. Sinonasal manifestations of Crohn’s disease are quite rare and only a few cases have been reported up to date in the worldwide literature. They are characterized by chronic mucosal in?ammation, obstruction, bleeding and occasionally septal perforation. We report a case of sinonasal granulomatosis revealing Crohn’s disease in a 22-year-old woman and go over the available literature on sinonasal involvement in Crohn’s disease.

View the entire article

Downloads

References

  1. Mamula P, Markowitz JE, Baldassano RN. Inflammatory bowel disease in early childhood and adolescence: special considerations, Gastroenterol Clin North Am 2003;32:967–995.
  2. Kriskovich MD, Kelly SM, Jackson WD. Nasal septal perforation: a rare extraintestinal manifestation of Crohn’s disease, Ear Nose Throat J 2000;79:520–523.
  3. Greenstein AJ, Janowitz HD, Sachar DB. The extra-intestinal complications of Crohn's disease and ulcerative colitis: a study of 700 patients, Medicine (Baltimore) 1976;55:401–412.
  4. Plauth M, Jenss H, Meyle J. Oral manifestations of Crohn’s disease: an analysis of 79 cases, J Clin Gastroenterol 1991;13:29–37.
  5. Dupuy A, Cosnes J, Revuz J, Delchier JC, Gendre JP, Cosnes A. Oral Crohn’s disease: clinical characteristics and long-term follow-up of 9 cases, Arch Dermatol 1999;135:439–442.
  6. Fatahzadeh M, Schwartz RA, Kapila R, Rochford C. Orofacial Crohn's disease: an oral enigma, Acta Dermatovenerol Croat 2009;17:289–300.
  7. Croft CB, Wilkinson AR. Ulceration of the mouth, pharynx, and larynx in Crohn's disease of the intestine, Br J Surg 1972;59:249–252.
  8. Bishop RP, Brewster AC, Antonioli DA. Crohn’s disease of the mouth, Gastroenterology 1972;62:302–306.
  9. Wilder WM, Slagle GW, Hand AM, Watkins WJ. Crohn’s disease of the epiglottis, aryepiglottic folds, anus, and rectum, J Clin Gastroenterol 1980;2:87–91.
  10. Sari S, Dalgic B, Yilmaz M, Poyraz A. Nasal septal perforation in an adolescent girl with Crohn's disease: a rare extraintestinal manifestation, Dig Dis Sci 2007;52:1285–1287.
  11. Grasso DL, Bussani M, Martelossi S. Choanal stenosis in Crohn’s disease: a case report and review of literature, Int J Pediatr Otorhinolaryngol 2007;2:228–230.
  12. Pellicano R, Sostegni R, Sguazzini C, Reggiani S, Astegiano M. A rare location of Crohn's disease: the nasal mucosa, Acta Biomed 2011;82:74–76.
  13. Oghan F, Pekkan G, Ozveren O. Saddle nose deformity, palatal perforation and truncus arteriosus in a patient with Crohn's disease, J Craniomaxillofac Surg 2012;40:17–19.
  14. Kryssia RC, Henry ZB. Nasal septum perforation: rare manifestation of Crohn's disease, Indian J Gastroenterol 2006;25:214.
  15. Eloy P, Leruth E, Goffart Y, Nollevaux MC, Fridman V, Dartevelle M et al. Sinonasal involvement as a rare extraintestinal manifestation of Crohn's disease, Eur Arch Otorhinolaryngol 2007;264:103–108.
  16. Van Deventer SJ. Anti-TNF antibody treatment of Crohn's disease, Ann Rheum Dis 1999;58:114–120.

Published

2014-10-01

Issue

Vol. 1 No. 1 (2014)

How to Cite

1.
Baili L, Rachdi I, Daoud F, Aydi Z, Ben Dhaou B, Kochbati S, et al. A Rare Manifestation of Crohn’s Disease: Sinonasal Granulomatosis. Report of a Case and Review of Literature. EJCRIM [Internet]. 2014 Oct. 1 [cited 2026 Nov. 3];1(1). Available from: https://ejcrim.com/index.php/ejcrim/article/view/123

Most read articles by the same author(s)