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Djalaleddine Ouakidi, Bouchra Nesrine Bourouis, Mohammed Amine Banat, Nesrine Azzi, Siham Benzait, Abdelmadjid Snouber
2023-09-15
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Introduction: Organising pneumonia belongs to diffuse interstitial lung diseases; we distinguish the cryptogenic organising pneumonia, which is idiopathic, from the secondary organising pneumonia caused by drugs or a defined cause. Denosumab is a human monoclonal antibody, rarely inducing adverse pulmonary effects.
Case description: A 57-year-old female patient was admitted to our chest clinic for acute respiratory distress. She was treated with denosumab for severe osteoporosis. The patient described a dry cough and dyspnoea over the previous four months, increased after the last injection of denosumab. A high-resolution computed tomography scan showed bilateral basal parenchymal condensations. The aetiological investigation did not reveal any infectious or immunological origin. The favourable computed tomography imaging and clinical evolution after corticosteroid therapy led to the diagnosis of drug-induced organising pneumonia.
Conclusion: Denosumab could induce organising pneumonia. Therefore, clinicians should be aware of this pulmonary toxicity.
Ana Campo Ruiz, Miguel F Carrascosa, Sergio Tapia Concha, Anibal Hernández Gil, Juan García Rivero
2019-07-03
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Denosumab is an antiresorptive agent widely used for treating osteoporosis. Atypical femur fractures, osteonecrosis of the jaw and hypocalcaemia are well-known possible adverse effects of this drug. We present, to our knowledge, the first case report in the English literature of clinically significant interstitial lung disease likely related to denosumab.
2.1 = | 1.762 Cit. to date |
842 Docs. to date |
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