A Rare Case of Bilateral Proptosis
  • Joao Fernandes Serodio
    Medicine IV Department, Hospital Prof. Doutor Fernando Fonseca, Amadora, Portugal
  • Marta Jonet
    Medicine IV Department, Hospital Prof. Doutor Fernando Fonseca, Amadora, Portugal
  • Miguel Trindade
    Medicine IV Department, Hospital Prof. Doutor Fernando Fonseca, Amadora, Portugal
  • Inês Coutinho
    Ophthalmology Department, Hospital Prof. Doutor Fernando Fonseca, Amadora, Portugal
  • Catarina Favas
    Medicine IV Department, Hospital Prof. Doutor Fernando Fonseca, Amadora, Portugal

Keywords

Palpebral MALT B-cell lymphoma, hepatitis C infection

Abstract

A 65-year-old man presented with a 2-year history of severe bilateral proptosis, palpable lymphadenopathy and moderate hepatosplenomegaly. A blood test was positive for hepatitis C infection. CT showed palpebral infiltrative lesions with regional progression through the temporal and masticatory spaces to the pharynx and hypopharynx causing almost complete airway obstruction. A palpebral biopsy was consistent with low-grade Bcl-2+ extra-nodal MALT non-Hodgkin B-cell lymphoma. The patient received six cycles of rituximab-based chemotherapy with clinical remission at 9-month follow-up. Bilateral proptosis is a rare presentation of several diseases. When brain CT excludes cavernous sinus pathology, thyroid ophthalmopathy or haematological malignancy should be considered.

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References

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  • Zucca E, Bertone F. The spectrum of MALT lymphoma at different sites: biological and therapeutic relevance. Blood 2016;127:2082–2092.

  • Tasleem S, Sood GK. Hepatitis C associated B-cell non-Hodgkin lymphoma: clinical features and the role of antiviral therapy. J Clin Transl Hepatol 2015;28:134–139.
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    Published: 2018-10-30
    Issue: Vol. 5 No. 11 (view)


    How to cite:
    1.
    Serodio JF, Jonet M, Trindade M, Coutinho I, Favas C. A Rare Case of Bilateral Proptosis. EJCRIM 2018;5 doi:10.12890/2018_000966.

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