Cryptococcal Meningitis in a HIV-Negative Patient

  • Cátia Barreiros Internal Medicine Department, Serviço de Medicina 1, Unidade Local de Saúde do Alto Minho, EPE, Portugal
  • Lúcia Meireles-Brandão Internal Medicine Department, Serviço de Medicina 1, Unidade Local de Saúde do Alto Minho, EPE, Portugal
  • Duarte Silva Internal Medicine Department, Serviço de Medicina 1, Unidade Local de Saúde do Alto Minho, EPE, Portugal
  • Carmélia Rodrigues Internal Medicine Department, Serviço de Medicina 1, Unidade Local de Saúde do Alto Minho, EPE, Portugal
  • Diana Guerra Internal Medicine Department, Serviço de Medicina 1, Unidade Local de Saúde do Alto Minho, EPE, Portugal

Abstract

Sarcoidosis is a risk factor for the development of cryptococcal infection due to dysfunction at T-cell level. Its rarity may, however, delay diagnosis and treatment. We describe the case of a 60-year-old man, diagnosed with sarcoidosis since 1999. He had never received systemic immunomodulatory therapy, such as corticosteroid therapy. In 2012, he was diagnosed with pulmonary cryptococcosis and treated with fluconazole. In April 2013, he presented with symptoms compatible with central nervous system (CNS) infection, namely, Cryptococcus neoformans meningitis. He was treated with amphotericin B, followed by fluconazole. The clinical outcome was favourable.

References

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  • Bernard C, Maucort-Boulch D, Varron L, Charlier C, Sitbon K, Freymond N, et al. Cryptococcosis in sarcoidosis: cryptOsarc, a comparative study of 18 cases. Q J Med 2013;106:523-39.

  • Adams T, Gibson M. Cryptococcal meningitis in a patient with sarcoidosis. Proc (Bayl Univ Med Cent) 2016;29:207-08.
  • Published: 2017-12-12

    Issue: Vol 5 No 2 (view)

    Section: Articles

    How to cite:
    Barreiros, C., Meireles-Brandão, L., Silva, D., Rodrigues, C., & Guerra, D. (2017). Cryptococcal Meningitis in a HIV-Negative Patient. European Journal of Case Reports in Internal Medicine, 5(2). https://doi.org/https://doi.org/10.12890/2017_000778