Cryptococcal Meningitis in a HIV-Negative Patient
  • Cátia Barreiros
    Internal Medicine Department, Serviço de Medicina 1, Unidade Local de Saúde do Alto Minho, EPE, Portugal
  • Lúcia Meireles-Brandão
    Internal Medicine Department, Serviço de Medicina 1, Unidade Local de Saúde do Alto Minho, EPE, Portugal
  • Duarte Silva
    Internal Medicine Department, Serviço de Medicina 1, Unidade Local de Saúde do Alto Minho, EPE, Portugal
  • Carmélia Rodrigues
    Internal Medicine Department, Serviço de Medicina 1, Unidade Local de Saúde do Alto Minho, EPE, Portugal
  • Diana Guerra
    Internal Medicine Department, Serviço de Medicina 1, Unidade Local de Saúde do Alto Minho, EPE, Portugal

Abstract

Sarcoidosis is a risk factor for the development of cryptococcal infection due to dysfunction at T-cell level. Its rarity may, however, delay diagnosis and treatment. We describe the case of a 60-year-old man, diagnosed with sarcoidosis since 1999. He had never received systemic immunomodulatory therapy, such as corticosteroid therapy. In 2012, he was diagnosed with pulmonary cryptococcosis and treated with fluconazole. In April 2013, he presented with symptoms compatible with central nervous system (CNS) infection, namely, Cryptococcus neoformans meningitis. He was treated with amphotericin B, followed by fluconazole. The clinical outcome was favourable.

VIEW THE ENTIRE ARTICLE

References

  • Leonhard S, Fritz D, van de Beek D, Brouwer M. Cryptococcal meningitis complicating sarcoidosis. Medicine 2016;95:e4587.

  • Bernard C, Maucort-Boulch D, Varron L, Charlier C, Sitbon K, Freymond N, et al. Cryptococcosis in sarcoidosis: cryptOsarc, a comparative study of 18 cases. Q J Med 2013;106:523-39.

  • Adams T, Gibson M. Cryptococcal meningitis in a patient with sarcoidosis. Proc (Bayl Univ Med Cent) 2016;29:207-08.
  • Views: 1249
    HTML downloads: 232
    PDF downloads: 523


    Published: 2017-12-12
    Issue: Vol. 5 No. 2 (view)


    How to cite:
    1.
    Barreiros C, Meireles-Brandão L, Silva D, Rodrigues C, Guerra D. Cryptococcal Meningitis in a HIV-Negative Patient. EJCRIM 2017;5 doi:10.12890/2017_000778.

    Most read articles by the same author(s)