Senile Systemic Amyloidosis: An Underdiagnosed Disease
  • Marta Catarino Manso
    Internal Medicine Department, Hospital de Egas Moniz, Lisbon
  • Diogo Paixão Marques
    Internal Medicine Department, Hospital de Egas Moniz, Lisbon
  • Sara L. Rocha
    Internal Medicine Department, Hospital de Egas Moniz, Lisbon
  • Simão C. Rodeia
    Emergency Department, Hospital Prof Doutor Fernando da Fonseca, Amadora
  • Raquel Domingos
    Internal Medicine Department, Hospital de Egas Moniz, Lisbon

Keywords

Cardiac amyloidosis, senile systemic amyloidosis, amyloidosis, heart failure with preserved ejection fraction.

Abstract

Senile systemic amyloidosis is caused by a non-mutated form of transthyretin with the heart being the major organ involved. This infiltrative cardiomyopathy usually presents as slowly progressive heart failure.
An 82-year-old female patient was admitted for newly diagnosed heart failure. A year later she presented with decompensated heart failure and syncope. Inpatient work-up showed persistently elevated troponin and N-terminal-pro BNP levels, rapid progression to severe left ventricular concentric hypertrophy, and sinus pauses on the Holter. Cardiac MRI revealed diffuse late gadolinium enhancement in the left ventricle. The demonstration of amyloid protein with the clinical findings and complementary investigations allowed for the diagnosis of senile systemic amyloidosis.

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    Published: 2017-09-21
    Issue: Vol. 4 No. 9 (view)

    How to cite:
    1.
    Manso MC, Paixão Marques D, Rocha SL, Rodeia SC, Domingos R. Senile Systemic Amyloidosis: An Underdiagnosed Disease. EJCRIM 2017;4 doi:10.12890/2017_000725.